Featured
-
-
Article
| Open AccessThe role of mechano-regulated YAP/TAZ in erectile dysfunction
Phosphodiesterase type 5 inhibitors (PDE5is) are used to treat erectile dysfunction, however, not all patients respond to PDE5i treatment. Here the authors report that YAP/TAZ activity contributes to erectile dysfunction and targeting YAP/TAZ improves erectile function in a PDE5i non-respondent rat model.
- Mintao Ji
- , Dongsheng Chen
- & Lei Chang
-
Article
| Open AccessSingle-cell transcriptome atlas of the human corpus cavernosum
The corpus cavernosum is the most important structure for penile erection, and its dysfunction causes physiological and psychological problems. Here the authors perform single-cell RNA-sequencing on corpus cavernosum samples from males with normal erection and erectile dysfunction patients, providing insights into this pathology.
- LiangYu Zhao
- , Sha Han
- & Zheng Li
-
Article
| Open AccessFunctional reconstruction of injured corpus cavernosa using 3D-printed hydrogel scaffolds seeded with HIF-1α-expressing stem cells
Injury of corpus cavernosa results in erectile dysfunction, and repair leading to restoration of function is difficult. Here the authors construct 3D printed hydrogel constructs seeded with HIF-1α-expressing muscle derived stem cells to restore corpus function in a rabbit model.
- Geng An
- , Feixiang Guo
- & Chuanbin Mao