Featured
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Letter |
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
WebTreatment of lipopolysaccharide-activated macrophages with the cell-permeable itaconate derivative 4-octyl itaconate activates the anti-inflammatory transcription factor Nrf2 by alkylating key cysteine residues on the KEAP1 protein.
- Evanna L. Mills
- , Dylan G. Ryan
- & Luke A. O’Neill
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Research Highlights |
How gut flora can turn deadly
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Research Highlights |
Immunity's circadian link
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News & Views |
A heavyweight knocked out
Caspase-1 is one of the main culprits behind sepsis, a form of systemic inflammation. The related enzyme caspase-11 is also involved, but the relative roles of the two proteins have been confusing, until now. See Letter p.117
- Douglas R. Green
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Letter |
Suppression of inflammation by a synthetic histone mimic
Post-translationally modified histones are recognized by effector proteins which contain specific binding modules; for example, the bromodomain-containing BET proteins bind acetylated lysine residues during gene activation. Here a synthetic small molecule is described that interferes with the binding of certain BET family members to acetylated histones. The compound inhibits activation of pro-inflammatory genes in macrophages and has activity in a mouse model of inflammatory disease.
- Edwige Nicodeme
- , Kate L. Jeffrey
- & Alexander Tarakhovsky
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Research Highlights |
Infectious disease: Battling bacterial blood infection
Induction of innate immune memory via microRNA targeting of chromatin remodelling factors