RNA probes articles within Nature Communications

Featured

• Article
  31 January 2024 | Open Access

  Fluorogenic CRISPR for genomic DNA imaging

  Conventional CRISPR-based approaches to monitor genomic loci can be hampered by high background and nonspecific nucleolar signal. Here, the authors propose a fluorogenic CRISPR (fCRISPR) tool that allows for high-contrast and sensitive imaging of genomic DNA.

  • Zhongxuan Zhang
  • , Xiaoxiao Rong
  •  & Xing Li

• Article | 09 October 2012

  Identifying the preferred RNA motifs and chemotypes that interact by probing millions of combinations

  Identifying molecules that bind to RNA is difficult because information about RNA–ligand interactions is limited. Tran and Disney report a solution-based screening method that can probe large numbers of RNA motif-small molecule interactions to identify privileged RNA structures and chemical spaces that interact.

  • Tuan Tran
  •  & Matthew D. Disney