Regeneration articles within Nature

Featured

  • Comment |

    Confusion about mesenchymal stem cells is making it easier for people to sell unproven treatments, warn Douglas Sipp, Pamela G. Robey and Leigh Turner.

    • Douglas Sipp
    • , Pamela G. Robey
    •  & Leigh Turner

  • News & Views |

    Spinal-cord injury can render intact neuronal circuits functionally dormant. Targeted reduction of neuronal inhibition in the injured region has now enabled reactivation of these circuits in mice, restoring basic locomotion.

    • Grégoire Courtine

  • Outline |

    Damage to the retina has so far proved irreversible, but stem-cell therapies could hold the key to restoring sight.

    • David Holmes

  • Outline |

    The ways in which lost vision might be restored are coming into focus as researchers move closer to recreating the eye’s most complex structure — the retina — in the laboratory.

    • David Holmes

  • Introduction |

    • Noah Gray
    • , Nathalie Le Bot
    •  & Marie-Thérèse Heemels

  • Editorial |

    The steady and careful development that has guided treatments using embryonic stem cells should be applied to therapies derived from adult stem cells, too.

  • News & Views |

    Cell-tracing analysis reveals that a disperse group of cells in the mouse liver express the enzyme telomerase, which preserves chromosome ends. These cells contribute to liver maintenance and regeneration.

    • Kenneth S. Zaret

  • Brief Communications Arising |

    • Jop H. van Berlo
    • , Onur Kanisicak
    •  & Jeffery D. Molkentin

  • News & Views |

    The assembly of genome sequences for the flatworm Schmidtea mediterranea and the salamander Ambystoma mexicanum will provide insights into the remarkable regenerative characteristics of these two organisms.

    • G. Parker Flowers
    •  & Craig M. Crews

  • Article
    | Open Access

    Sequencing and assembly of the 32-Gb genome of the Mexican axolotl reveals that it lacks the developmental gene Pax3, which is essential in other vertebrates; the genome sequence could improve our understanding of the evolution of the axolotl’s remarkable regenerative capabilities.

    • Sergej Nowoshilow
    • , Siegfried Schloissnig
    •  & Eugene W. Myers

  • Outline |

    At present, there is no way to reverse damage to the spinal cord or to restore lost function. But regenerative therapies in the initial stages of clinical testing are offering hope.

    • David Holmes

  • News & Views |

    The treatment of a patient affected by an incurable genetic skin disease demonstrates the efficacy, feasibility and safety of replacing almost the whole skin using genetically corrected stem cells. See Letter p.327

    • Mariaceleste Aragona
    •  & Cédric Blanpain

  • Outline |

    A bone fracture that fails to heal after initial treatment can lead to prolonged disability. Regenerative therapies might help to restart the bone-healing process, getting the people affected back in action.

    • David Holmes

  • Outline |

    Many people with critical limb ischaemia have no option but to have the affected limb amputated. Can regenerative medicine offer an alternative?

    • David Holmes

  • Letter |

    Intravital imaging reveals unanticipated plasticity of adult skin epithelium in mice when faced with mutational or non-mutational insults, and elucidates the dynamic cellular behaviours used for its return to a homeostatic state.

    • Samara Brown
    • , Cristiana M. Pineda
    •  & Valentina Greco

  • News & Views |

    The development of a protocol for isolating and expanding the cell population that lines bile ducts has enabled the in vitro generation of bioengineered ducts. These can replace native bile ducts when transplanted into mice.

    • Ludi Zhang
    •  & Lijian Hui

  • Outline |

    Damage to the surface of the cornea causes pain and loss of vision, but regenerative therapies are providing a clearer, brighter future.

    • David Holmes

  • Outline |

    Loss of the stem cells that constantly renew the surface of the cornea causes pain and, in some cases, blindness. Advances in transplantation and cell culture are helping to restore vision to even the most severely affected people.

    • David Holmes

  • Article |

    During emergency myelopoiesis in mice, clusters of self-renewing granulocyte/macrophage progenitors (GMP) are transiently formed in the bone marrow cavity to produce a burst of myeloid cells; in leukaemia, GMP clusters persist and constantly generate myeloid leukaemia cells.

    • Aurélie Hérault
    • , Mikhail Binnewies
    •  & Emmanuelle Passegué

  • News & Views |

    A mouse pancreas grown in a rat controls blood-sugar levels when transplanted into a mouse that models type 1 diabetes. This achievement provides a tantalizing glimpse of how organs could be grown for therapeutic use. See Article p.191

    • Qiao Zhou

  • Article |

    The authors inject mouse pluripotent stem cells into pancreatogenesis-disabled rat blastocysts and thereby generate rats with mouse pancreata from which the islets, when transplanted into mice, can provide a long-term cure for symptoms of diabetes, without continuous immunosuppression.

    • Tomoyuki Yamaguchi
    • , Hideyuki Sato
    •  & Hiromitsu Nakauchi

  • Outlook |

    Advances in technology have outpaced our understanding of organ development and injury response. It's time to reassess, says Stephen Badylak.

    • Stephen Badylak

  • Outlook |

    For centuries, scientists have been captivated by the phenomenal feats of regeneration found in nature. Despite decades of research, attempts to replace or repair parts of the human body have met with only modest success. Fresh understanding of organ formation coupled with new technologies may help to unlock long-sought cures.

    • Cassandra Willyard

  • Outlook |

    Stem-cell therapy promises to restore motor function after a stroke or spinal-cord injury, but neurologists are proceeding with caution.

    • Katherine Bourzac

  • Outlook |

    Adult stem cells have become a regulatory battleground as clinicians, scientists and ethicists debate whether the road to the clinic should be shorter.

    • Michael Eisenstein

  • News & Views |

    Retinal-cell transplants restore vision in mouse models of retinal degeneration. It emerges that the transplant leads to an exchange of material between donor and host cells — not to donor-cell integration into the retina, as had been presumed.

    • Michael A. Dyer

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