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Article
| Open Access
A direction-selective cortico-brainstem pathway adaptively modulates innate behaviors
The visual cortex adapts innate behaviors through its corticofugal projections to the brainstem. Here, authors show that this pathway sends unique brainstem neurons distinct behaviorally relevant signals, whose strength can plastically change to promote behavioral adaptation.
- Jiashu Liu
- , Yingtian He
- & Bao-hua Liu
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Article
| Open Access
Presynaptic gating of monkey proprioceptive signals for proper motor action
The role of presynaptic modulation on peripheral sensory input during voluntary movement is unclear. Here, the authors found it flexibly facilitates and suppresses proprioceptive input to the monkey’s spinal cord, relevant to motor behavior.
- Saeka Tomatsu
- , GeeHee Kim
- & Kazuhiko Seki
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Article
| Open Access
Purkinje cell microzones mediate distinct kinematics of a single movement
Purkinje cells form a diverse population, but how diversity contributes to cerebellar behavior is not fully understood. Here, the authors reveal how nuances in molecular signatures correlate with electrophysiological, anatomical, and ultimately functional differences among Purkinje cell subpopulations.
- François G. C. Blot
- , Joshua J. White
- & Martijn Schonewille
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Article
| Open Access
Biomechanics and neural circuits for vestibular-induced fine postural control in larval zebrafish
The postural control mechanism in fish is unclear. Here, authors show that larval zebrafish recover upright posture after roll tilts by a body bend that produces corrective rotational torque. They also reveal the associated neural circuits and muscles.
- Takumi Sugioka
- , Masashi Tanimoto
- & Shin-ichi Higashijima
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Article
| Open Access
Intrafusal-fiber LRP4 for muscle spindle formation and maintenance in adult and aged animals
Muscle spindles sense muscle tension to coordinate body movement. This paper reveals a mechanism of spindle formation and maintenance and to better understanding changes in movement in muscle disorders and ageing.
- Rangjuan Cao
- , Peng Chen
- & Lin Mei
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Article
| Open Access
Organization of the gravity-sensing system in zebrafish
How sensory systems are organized during development remains unclear. Here, the authors used electron microscopy to examine the gravity-sensing system in zebrafish, finding that directional tuning and developmental age are organizing principles of the transformation from vestibular sensation to motor control.
- Zhikai Liu
- , David G. C. Hildebrand
- & Martha W. Bagnall
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Article
| Open Access
Locomotion-induced ocular motor behavior in larval Xenopus is developmentally tuned by visuo-vestibular reflexes
Visual perception works best when eye movement counteracts the effects of body movement. This study describes how such coordination first emerges and matures during development in frog larvae.
- Julien Bacqué-Cazenave
- , Gilles Courtand
- & François M. Lambert
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Article
| Open Access
A cerebellar internal model calibrates a feedback controller involved in sensorimotor control
Animals can adjust their behavior in response to changes in the environment when these changes can be predicted. Here the authors show the role of the cerebellum in zebrafish that change their swimming as they adjust to long-lasting changes in visual feedback
- Daniil A. Markov
- , Luigi Petrucco
- & Ruben Portugues
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Article
| Open Access
A Brainstem reticulotegmental neural ensemble drives acoustic startle reflexes
The function of brainstem reticulotegmental nucleus (RtTg) and its related circuits are not fully understood. Here, the authors report a cochlear nucleus-RtTg-spinal motor neuron circuit that specifically mediates acoustic startle reflexes.
- Weiwei Guo
- , Sijia Fan
- & Wei Xiong
Cerebellar Purkinje cells combine sensory and motor information to predict the sensory consequences of active self-motion in macaques