Pox virus | Nature

Article
09 August 2023 | Open Access

TRIM5α restricts poxviruses and is antagonized by CypA and the viral protein C6

The well-characterized HIV restriction factor TRIM5α also restricts orthopoxviruses and is countered by the viral protein C6 and the proviral activity of CypA, which in turn is antagonized by CsA and derivatives alisporivir and NIM811.

Yiqi Zhao
, Yongxu Lu
& Geoffrey L. Smith

Letter | 21 June 2017

Trans-kingdom mimicry underlies ribosome customization by a poxvirus kinase

The poxvirus vaccinia virus phosphorylates serine/threonine residues in the human small ribosomal subunit RACK1, converting it to a plant-like state to favour translation of poxvirus mRNAs

Sujata Jha
, Madeline G. Rollins
& Derek Walsh

Letter | 29 February 2012

Skin infection generates non-migratory memory CD8⁺ T_RM cells providing global skin immunity

Local skin infection is shown to generate long-lived T cells that reside throughout the skin and are potent effector cells, superior to circulating memory T cells in providing rapid long-term protection again cutaneous re-infection.

Xiaodong Jiang
, Rachael A. Clark
& Thomas S. Kupper

Letter | 31 August 2011

Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans

Caroline J. Breitbach
, James Burke
& David H. Kirn

Editorial | 19 January 2011

Smallpox should be saved

Secure virus stocks in the United States and Russia may still prove useful and should not be destroyed. A political compromise is the best way to make that happen.

Obituary | 05 January 2011