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HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation
Assembly of a catalytic centre formed by HPF1 bound to PARP1 or PARP2 is essential for protein ADP-ribosylation after DNA damage in human cells.
- Marcin J. Suskiewicz
- , Florian Zobel
- & Ivan Ahel
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Letter |
Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal
Structural and biochemical approaches are used to show how RNF146 activity is allosterically regulated by the binding of poly(ADP-ribose) ligand, and how substrate specificity is achieved with protein poly(ADP-ribosyl)ation and ubiquitination occurring in the same protein complex.
- Paul A. DaRosa
- , Zhizhi Wang
- & Wenqing Xu