Pituitary tumours articles within Nature Communications

Featured

• Article
  05 November 2018 | Open Access

  Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours

  LncRNA H19 has been shown to be aberrantly expressed in different cancers. Here, the authors show that H19 lncRNA is downregulated in pituitary adenomas and H19 is able to impede pituitary tumorigenesis via disruption of 4E-BPB1 and Raptor interaction to inhibit the phosphorylation of 4E-BP1.

  • Ze Rui Wu
  • , Lichong Yan
  •  & Zhe Bao Wu

• Article
  09 August 2018 | Open Access

  Identification of recurrent USP48 and BRAF mutations in Cushing’s disease

  In this study the authors report USP48 and BRAF are frequently mutated in USP8 wild-type corticotroph adenomas, and cause Cushing’s disease mainly through promoting the promoter activity of POMC. Inhibition of BRAF may be a promising therapeutic strategy for the treatment of patients with BRAF-mutated corticotroph adenomas.

  • Jianhua Chen
  • , Xuemin Jian
  •  & Yongyong Shi

• Article | 17 March 2014

  Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity

  The pRb target E2F1 possesses contradictory activities in promoting proliferation and apoptosis. Here, the authors define a pRb-Skp2-p27-cyclin A-E2F1 survival pathway that can be disrupted to prevent Rb1-deficient tumorigenesis in the pituitary intermediate lobe.

  • Zhonglei Lu
  • , Frederick Bauzon
  •  & Liang Zhu