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| Open AccessAn ancient family of lytic polysaccharide monooxygenases with roles in arthropod development and biomass digestion
LPMOs catalyze the oxidative breakdown of polysaccharides, thereby facilitating biomass degradation. By analyzing the digestive proteome of firebrats, the authors here identify a yet uncharacterized LPMO family and provide phylogenetic, structural and biochemical insights into its origin and functions.
- Federico Sabbadin
- , Glyn R. Hemsworth
- & Simon J. McQueen-Mason
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Article
| Open AccessPlanctomycetes do possess a peptidoglycan cell wall
Planctomycetes appear to differ from all other bacteria in their cellular organization and their apparent lack of a peptidoglycan (PG) cell wall. Here Jeske et al. show that Planctomycetes do possess a typical PG cell wall and that their cellular architecture resembles that of Gram-negative bacteria.
- Olga Jeske
- , Margarete Schüler
- & Christian Jogler
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Hippos stem from the longest sequence of terrestrial cetartiodactyl evolution in Africa
The evolutionary origin of Hippopotamidae, the family of hippos, is poorly understood. Here, the authors describe a new fossil from Kenya that unambiguously roots Hippopotamidae into the group that includes the first large terrestrial mammals to invade Africa, more than 30 million years ago.
- Fabrice Lihoreau
- , Jean-Renaud Boisserie
- & Stéphane Ducrocq
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Article
| Open AccessTipping elements in the human intestinal ecosystem
Intestinal microbes can have important effects on our health. Here, the authors analyse the gut microbiota composition in 1,000 western adults and find that certain bacteria are either abundant or nearly absent, and that these alternative states are associated with ageing and overweight.
- Leo Lahti
- , Jarkko Salojärvi
- & Willem M. de Vos
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PhyloPhlAn is a new method for improved phylogenetic and taxonomic placement of microbes
Sequencing whole microbial genomes has become standard practice and methods to examine their phylogenetic relationships need to match the increasing demand. Segata et al. present a new computational pipeline that allows fast and accurate taxonomic assignment of microbial species.
- Nicola Segata
- , Daniela Börnigen
- & Curtis Huttenhower
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A novel methodology for large-scale phylogeny partition
Phylogenetic analysis is used to identify transmission chains, but no software is available for the automated partition of large phylogenies. Prosperiet al. apply a new search algorithm to identify transmission clusters within the phylogeny of HIV-1gene sequences linking molecular and epidemiological data.
- Mattia C.F. Prosperi
- , Massimo Ciccozzi
- & Andrea De Luca
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Article
| Open AccessEffector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations
Leptosphaeria maculans is a plant pathogen that causes stem canker of oilseed rape. Rouxel et al. sequence and describe the key features of the L. maculansgenome, including partitioning into AT-rich blocks that are enriched in effector genes and transposable elements affected by repeat-induced point mutation.
- Thierry Rouxel
- , Jonathan Grandaubert
- & Barbara J. Howlett