Pharmacokinetics articles within Nature

Featured

• Letter | 16 August 2017

  Vaccine-driven pharmacodynamic dissection and mitigation of fenethylline psychoactivity

  A vaccine-driven approach shows that the prominent stimulant features of the psychoactive profile of fenethylline can be attributed to amphetamine, with synergistic support from theophylline, and no direct contributions from the parent drug molecule.

  • Cody J. Wenthur
  • , Bin Zhou
  •  & Kim D. Janda

• Article | 04 May 2016

  NMDAR inhibition-independent antidepressant actions of ketamine metabolites

  The metabolism of ketamine to (2S,6S;2R,6R)-hydroxynorketamine (HNK) is essential for its antidepressant effects, and the (2R,6R)-HNK enantiomer lacks ketamine-related side effects but exerts rapid and sustained antidepressant actions in mice; these antidepressant effects are independent of NMDAR inhibition but require AMPAR activity.

  • Panos Zanos
  • , Ruin Moaddel
  •  & Todd D. Gould

• News | 11 July 2011

  Mice with human livers deal with drugs the human way

  'Humanized' mice could provide better assessment of drugs' toxicity for humans.

  • Marian Turner