Pharmacogenomics articles within Nature

Featured

• Letter | 28 August 2013

  A statin-dependent QTL for GATM expression is associated with statin-induced myopathy

  Exploration of the interacting effect of statin exposure and genetic variation on gene expression identifies a cis-eQTL that is differentially associated with expression of the GATM gene, which encodes a rate-limiting enzyme involved in creatine synthesis, and that is associated with incidence of statin-induced myopathy, the major adverse effect of statin treatment.

  • Lara M. Mangravite
  • , Barbara E. Engelhardt
  •  & Ronald M. Krauss

• Article | 28 March 2012

  Systematic identification of genomic markers of drug sensitivity in cancer cells

  Human cancer cell lines are screened with drugs, undergoing clinical or preclinical investigation, to determine specific genomic alterations associated with response to therapeutic agents.

  • Mathew J. Garnett
  • , Elena J. Edelman
  •  & Cyril H. Benes

• Outlook | 08 June 2011

  Pharmacogenomics: Playing the odds

  Can doctors calculate a patient's chance of being cured by searching their DNA? Hepatitis C researchers are starting to make this a reality.

  • Amy Maxmen

• News & Views Forum | 16 February 2011

  Drugs, diabetes and cancer

  Variation in a genomic region that contains the cancer-associated gene ATM affects a patient's response to the diabetes drug metformin. Two experts discuss the implications for understanding diabetes and the link to cancer.

  • Morris J. Birnbaum
  •  & Reuben J. Shaw