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| Open AccessInflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation
The shared genetics between upper respiratory diseases have not been well studied. Here, the authors find shared and distinct genetic loci for pharyngeal and sinonasal inflammatory conditions, which show shared heritability with autoimmune conditions and immune deficiency, highlighting the TNFR2 pathway.
- Elmo C. Saarentaus
- , Juha Karjalainen
- & Aarno Palotie
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Article
| Open AccessOsteocytes directly regulate osteolysis via MYD88 signaling in bacterial bone infection
MYD88 mediates the signal of bacterial infection. Here, in the context of periodontal infection, the authors show that the MYD88 pathway in osteocytes plays a dominant role in regulating osteolysis.
- Tetsuya Yoshimoto
- , Mizuho Kittaka
- & Yasuyoshi Ueki
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Article
| Open AccessNanoparticulate cell-free DNA scavenger for treating inflammatory bone loss in periodontitis
Periodontitis is a common type of inflammatory bone loss, and cell-free DNA (cfDNA) can be a major source that enhances the periodontal tissue destruction. Here, the authors show that a cfDNA-scavenging approach is able to ameliorate periodontitis by using nanoparticulate cfDNA scavenger.
- Hanyao Huang
- , Weiyi Pan
- & Kam W. Leong
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Article
| Open AccessGingival solitary chemosensory cells are immune sentinels for periodontitis
Solitary chemosensory cells (SCCs) expressing taste receptors reside in mucosal epithelia including the gingiva. Here the authors show that ablation of taste-sensing by SSCs leads to outgrowth of pathogenic oral bacteria and periodontitis, whereas bitter taste receptor stimulation promotes antimicrobial peptide production and ameliorates periodontitis.
- Xin Zheng
- , Marco Tizzano
- & Robert F. Margolskee
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Article
| Open AccessGWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation
IL-1β in gingival crevicular fluid (GCF) is a marker of inflammation in periodontal disease. Here, Offenbacher et al. identify genetic variants in the IL37 locus associated with GCF-IL-1β and show that the IL-1β-increasing allele at rs3811046 leads to an enhanced inflammatory response in vitro and in vivo.
- Steven Offenbacher
- , Yizu Jiao
- & Kari E. North