Featured
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Research Highlights |
Evolutionary biology: Colourful bacterial resistance
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Letter |
Branched tricarboxylic acid metabolism in Plasmodium falciparum
A central hub of carbon metabolism is the tricarboxylic acid (TCA) cycle, which serves to connect the processes of glycolysis, gluconeogenesis, respiration, amino acid synthesis and other biosynthetic pathways. These authors show that TCA metabolism in the human malaria parasite Plasmodium falciparum is largely disconnected from glycolysis and is organized along a fundamentally different architecture — not cyclic, but branched — from the canonical textbook pathway.
- Kellen L. Olszewski
- , Michael W. Mather
- & Manuel Llinás
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News & Views |
Malaria parasite stands out
One of the hallmarks of cellular biochemistry is the ability to extract energy efficiently from available substrates. The malaria parasite, however, deviates from the norm, and has come up with its own solution.
- Hagai Ginsburg