Featured
-
-
Article
| Open Access
A neomorphic variant in SP7 alters sequence specificity and causes a high-turnover bone disorder
SP7 is a transcription factor required for osteoblast differentiation and bone formation. A neomorphic mutation in SP7 was found to alter DNA binding specificity, causing a complex skeletal disorder in both mice and humans.
- Julian C. Lui
- , Adalbert Raimann
- & Jeffrey Baron
-
Article
| Open Access
RSPO3 is important for trabecular bone and fracture risk in mice and humans
Genetic association signals for fractures have been reported at the RSPO3 locus, but the causal gene and the underlying mechanism are unknown. Here, the authors show that RSPO3 exerts an important role for vertebral trabecular bone mass and bone strength in mice and fracture risk in humans.
- Karin H. Nilsson
- , Petra Henning
- & Claes Ohlsson
-
Article
| Open Access
Identification of osteogenic progenitor cell-targeted peptides that augment bone formation
Activation of osteogenic cells is essential for bone regeneration. Here, the authors screen a peptide library and identify 2 compounds that promote osteogenic progenitor cell differentiation in vitro, and show that they increase bone formation and fracture repair in mice.
- Min Jiang
- , Ruiwu Liu
- & Wei Yao
-
Article
| Open Access
Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo
Communication between osteoblasts and osteoclasts is essential for bone homeostasis, but the mode of interaction is unclear. The authors use intravital two-photon microscopy in mice to show that these cells directly interact, regulating activity of osteoclasts, and that the interaction is modulated by parathyroid hormone administration.
- Masayuki Furuya
- , Junichi Kikuta
- & Masaru Ishii
-
Article |
NAA10 controls osteoblast differentiation and bone formation as a feedback regulator of Runx2
N-alpha-acetyltransferase 10 (NAA10) regulates cell growth and proliferation. Here the authors show that NAA10 also has a role in osteogenesis, by fine-tuning the activity of the osteogenic transcription factor Runx2.
- Haejin Yoon
- , Hye-Lim Kim
- & Jong-Wan Park
-
Article |
c-Src and IL-6 inhibit osteoblast differentiation and integrate IGFBP5 signalling
Osteoblast maturation is regulated by c-Src and IL-6, but how these signalling pathways are integrated is not known. Here c-Src is shown to induce 1GFBP5 in immature osteoblasts in a STAT3 and IL-6-dependent manner, in mature osteoblasts, which express lower levels of c-Src, this signalling is lost.
- Barbara Peruzzi
- , Alfredo Cappariello
- & Anna Teti
Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo