NMR spectroscopy articles within Nature Communications

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  • Article
    | Open Access

    α-synuclein, a protein associated to Parkinson's disease, is involved in synaptic vesicle interaction and assembly. Here, the authors use NMR spectroscopy and super-resolution microscopy to unveil the nature and molecular mechanism of α-synuclein-mediated synaptic vesicle clustering.

    • Giuliana Fusco
    • , Tillmann Pape
    •  & Alfonso De Simone

  • Article
    | Open Access

    To modulate gene expression, the glucocorticoid receptor binds to response elements (RE) that vary in sequence. Here, the authors show that RE sequences can modulate glucocorticoid receptor structure and activity, which might provide regulatory specificity towards individual target genes.

    • Stefanie Schöne
    • , Marcel Jurk
    •  & Sebastiaan H. Meijsing

  • Article
    | Open Access

    The chlorosome of the photosynthetic bacterium C. tepidumharvests light and transfers the energy to the photosynthetic reaction centre. Here the authors determine the structure of the baseplate, a scaffolding super-structure, to show that the baseplate consists of rods of repeated CsmA dimers containing pigment molecules.

    • Jakob Toudahl Nielsen
    • , Natalia V. Kulminskaya
    •  & Niels Chr. Nielsen

  • Article
    | Open Access

    Chromosomal single-strand DNA breaks occur frequently and require repair to avoid disease outcomes. Here, the authors show that in bird cells, PARP3 accelerates this repair, and use structural biology and cell biology techniques to reveal details of the mechanism of action.

    • Gabrielle J. Grundy
    • , Luis M. Polo
    •  & Keith W. Caldecott

  • Article
    | Open Access

    Despite its importance to the cement industry, tricalcium silicate hydration, with its sequence of induction, acceleration and deceleration steps, still hosts many open questions. Here, 29Si nuclear magnetic resonance provides new information on the silicate polymerization mechanism and its kinetics.

    • Elizaveta Pustovgar
    • , Rahul P. Sangodkar
    •  & Jean-Baptiste d’Espinose de Lacaillerie

  • Article
    | Open Access

    Laplace NMR provides complementary information to traditional NMR, such as details of molecular motion. Here, the authors report a correlation experiment capable of providing information on the physical environment of molecules while enhancing the chemical resolution and greatly reducing the experiment times.

    • Susanna Ahola
    • , Vladimir V Zhivonitko
    •  & Ville-Veikko Telkki

  • Article
    | Open Access

    Covalency is a fundamental concept in chemical bonding, but experimentally it is not possible to measure the degree of covalency of a particular bond. Here, the authors report a model to link the covalency of hydrogen bonds in water with the anisotropy of the magnetic shielding tensor in the proton NMR.

    • Hossam Elgabarty
    • , Rustam Z. Khaliullin
    •  & Thomas D. Kühne

  • Article
    | Open Access

    G-protein-coupled receptors (GPCRs) signal via G proteins or arrestin-mediated pathways; the plasticity of arrestin proteins is thought to underlie their function. Here, the authors use NMR to examine how β-arrestin-1 recognizes different GPCR phospho-barcodes, and how this triggers structural rearrangements to fulfill selective functions.

    • Fan Yang
    • , Xiao Yu
    •  & Jin-Peng Sun

  • Article
    | Open Access

    The determination of RNA structures within high-molecular weight protein-RNA complexes in non-crystalline state is technically challenging. Here, the authors describe a solid-state NMR protocol for the determination of RNA structures at high resolution.

    • Alexander Marchanka
    • , Bernd Simon
    •  & Teresa Carlomagno

  • Article
    | Open Access

    The nature and universality of the ordering phenomena observed in the normal state of high-temperature superconductors remain unclear. Here, Wu et al. observe several aspects of incipient charge ordering in YBCO via NMR measurements, clarifying the role of quenched disorder in their emergence.

    • Tao Wu
    • , Hadrien Mayaffre
    •  & Marc-Henri Julien

  • Article |

    Mutations in the enzyme superoxide dismutase 1 (SOD1) underlie a form of neurodegenerative disease called amyotrophic lateral sclerosis. Here the authors employ in-cell NMR to show that SOD1 mutants adopt unstructured conformations that are unable to bind zinc and may form toxic SOD1 aggregates.

    • Enrico Luchinat
    • , Letizia Barbieri
    •  & Lucia Banci

  • Article |

    Solving structures of large protein complexes remains a significant challenge for structural biologists. Demers et al. determine the atomic structure of a Shigellatype-III secretion system using a Rosetta-based modelling strategy that draws on both solid-state NMR and cryo-electron microscopy data sets.

    • Jean-Philippe Demers
    • , Birgit Habenstein
    •  & Nikolaos G. Sgourakis

  • Article
    | Open Access

    Nuclear magnetic resonance spectroscopy is a powerful technique that can identify the presence of certain atoms in a sample by their magnetic properties. Müller et al.now take this concept to its ultimate limit by measuring individual nuclear spins near the surface of diamond.

    • C. Müller
    • , X. Kong
    •  & F. Jelezko

  • Article |

    Hyperpolarized 129Xe gas is used as a contrast agent in nuclear magnetic resonance imaging. Here, the authors demonstrate a microfluidic chip that optically polarizes 129Xe gas for compact nuclear magnetic resonance imaging applications.

    • Ricardo Jiménez-Martínez
    • , Daniel J. Kennedy
    •  & John Kitching

  • Article |

    Understanding structural transformations of electrodes during cycling is of significance in batteries. Here Ogata et al. develop an approach for probing (de)lithiation processes in nano-silicon by in situNMR spectroscopy, which reveals structural and kinetic insights into the lithium–silicide phase transformations.

    • K. Ogata
    • , E. Salager
    •  & C.P. Grey

  • Article |

    Nuclear magnetic resonance spectroscopy is a powerful analytical tool, but suffers from low resolution and the need for complex equipment. Fratila et al. develop a non-resonant planar transceiver microcoil that enables low-volume heteronuclear detection in a broad frequency range with high resolution.

    • Raluca M. Fratila
    • , M. Victoria Gomez
    •  & Aldrik H. Velders

  • Article
    | Open Access

    Nuclear magnetic resonance is vital for analysis and diagnostics but suffers from insensitivity as only a small fraction of all NMR-active nuclei are spin-polarized and contribute to the signal. Here Hövener et al. describe an effect that replenishes nuclear spin polarization continuously for a considerably enhanced performance at low field.

    • Jan-Bernd Hövener
    • , Niels Schwaderlapp
    •  & Dominik von Elverfeldt

  • Article
    | Open Access

    The enantiopurity of chiral compounds is key in determining their activity or therapeutic action. Here, the authors present a versatile NMR method of enantiomeric excess determination using a symmetrical achiral molecule as resolving agent, based on complexation with analyte, without formation of diastereomers.

    • Jan Labuta
    • , Shinsuke Ishihara
    •  & Jonathan P. Hill

  • Article
    | Open Access

    Binary mixtures of molecules on the surface of nanoparticles can arrange randomly or into different domains to form Janus, patchy or striped particles. Liuet al.show that NMR can be used to determine the ligand-shell morphology of particles coated with aliphatic and aromatic ligands.

    • Xiang Liu
    • , Miao Yu
    •  & Francesco Stellacci

  • Article
    | Open Access

    Magnesium is an ideal rechargeable battery anode material, but coupling it with a low-cost sulphur cathode, requires a non-nucleophilic electrolyte. Kimet al. prepare a non-nucleophilic electrolyte from hexamethyldisilazide magnesium chloride and aluminium trichloride, and show its compatibility with a sulphur cathode.

    • Hee Soo Kim
    • , Timothy S. Arthur
    •  & John Muldoon

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