Featured
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Letter |
The centrosome protein AKNA regulates neurogenesis via microtubule organization
The interphase centrosome protein AKNA is necessary and sufficient for the organization of centrosomal microtubules, mediates delamination in the formation of the subventricular zone and regulates exit from this zone.
- Germán Camargo Ortega
- , Sven Falk
- & Magdalena Götz
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Letter |
Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size
In a ferret model, the microcephaly-associated gene Aspm regulates cortical expansion by controlling the transition of ventricular radial glial cells to more differentiated cell types.
- Matthew B. Johnson
- , Xingshen Sun
- & Byoung-Il Bae
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Letter |
Radial glia require PDGFD–PDGFRβ signalling in human but not mouse neocortex
The transcriptional profiles of radial glia are compared between humans and mice during neurogenesis, implicating the growth factor PDGFD and its receptor, PDGFRβ, in human but not mouse neocortical development.
- Jan H. Lui
- , Tomasz J. Nowakowski
- & Michael C. Oldham
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Article |
Transcriptional landscape of the prenatal human brain
A spatially resolved transcriptional atlas of the mid-gestational developing human brain has been created using laser-capture microdissection and microarray technology, providing a comprehensive reference resource which also enables new hypotheses about the nature of human brain evolution and the origins of neurodevelopmental disorders.
- Jeremy A. Miller
- , Song-Lin Ding
- & Ed S. Lein
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Article |
Temporal patterning of Drosophila medulla neuroblasts controls neural fates
Five transcription factors are sequentially expressed in a temporal cascade in Drosophila medulla neuroblasts of the visual system; cross-regulations between these transcription factors control the temporal transitions, and temporal switching of neural progenitors may be a common theme in neuronal specification, with different sequences of transcription factors being used in different contexts.
- Xin Li
- , Ted Erclik
- & Claude Desplan
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News & Views |
The neuron family tree remodelled
The discovery of different classes of neuronal progenitor cell, destined to give rise to neurons in specific layers of the cerebral cortex, could presage the revision of a 50-year-old model of brain development.
- Oscar Marín
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Article |
Neurogenic radial glia in the outer subventricular zone of human neocortex
In the mammalian brain, the subventricular zone (SVZ) produces neural progenitor cells that migrate into the cortex to populate the upper layers. In humans this region is massively expanded, producing an outer SVZ (OSVZ). Here, live-cell imaging of developing human tissue was used to show that the OSVZ has similar characteristics to the SVZ, with progenitor cells proliferating in a way that depends on the Notch protein. The findings have implications for our understanding of how the complex human brain evolved.
- David V. Hansen
- , Jan H. Lui
- & Arnold R. Kriegstein
Patterned cPCDH expression regulates the fine organization of the neocortex