Natural product synthesis articles within Nature

Featured

  • Article |

    Computers equipped with a comprehensive knowledge-base of mechanistic steps augmented by physical-organic chemistry rules, as well as quantum mechanical and kinetic calculations, can use a reaction-network approach to analyse the mechanisms of cationic rearrangements.

    • Tomasz Klucznik
    • , Leonidas-Dimitrios Syntrivanis
    •  & Bartosz A. Grzybowski

  • Article |

    A scalable total synthesis of portimines enables structural reassignment of portimine B and in-depth functional evaluation of portimine A, revealing that portimine A induces translation inhibition selectively in human cancer cells and is efficacious in vivo tumour-clearance models.

    • Junchen Tang
    • , Weichao Li
    •  & Phil S. Baran

  • Article
    | Open Access

    Chimeric triterpene synthases are identified that catalyse non-squalene-dependent triterpene biosynthesis.

    • Hui Tao
    • , Lukas Lauterbach
    •  & Tiangang Liu

  • Article |

    A synthetic route to GB18, an alkaloid from the bark of hallucinogenic Galbulimima sp., is developed, enabling its identification as an antagonist of κ- and μ-opioid receptors.

    • Stone Woo
    •  & Ryan A. Shenvi

  • Article
    | Open Access

    Methicillin-resistant strains of Staphylococcus aureus appeared in European hedgehogs in the pre-antibiotic era as a co-evolutionary adaptation to antibiotic-producing dermatophytes and have spread within the local hedgehog populations and between hedgehogs and secondary hosts.

    • Jesper Larsen
    • , Claire L. Raisen
    •  & Anders R. Larsen

  • Article |

    A synthetic route-planning algorithm, augmented with causal relationships that allow it to strategize over multiple steps, can design complex natural-product syntheses that are indistinguishable from those designed by human experts.

    • Barbara Mikulak-Klucznik
    • , Patrycja Gołębiowska
    •  & Bartosz A. Grzybowski

  • Article |

    Modular synthesis and structural biology are used to design and characterize group A streptogramin antibiotics, one of which has activity against streptogramin-resistant strains and demonstrates efficacy in a mouse model of bacterial infection.

    • Qi Li
    • , Jenna Pellegrino
    •  & Ian B. Seiple

  • Letter |

    Microbial generation of a terminal-alkyne-containing amino acid can be encoded into E. coli and provides the potential for in vivo generation of proteins and natural products for click chemistry.

    • J. A. Marchand
    • , M. E. Neugebauer
    •  & M. C. Y. Chang

  • Letter |

    Starting with alkyl carboxylic acids, a simple olefin synthesis using any substitution pattern or geometry, based on amide-bond synthesis with nickel- or iron-based catalysis, is described.

    • Jacob T. Edwards
    • , Rohan R. Merchant
    •  & Phil S. Baran

  • Article |

    A practical, fully synthetic route to macrolide antibiotics via the convergent assembly of simple chemical building blocks is described; more than 300 new macrolide antibiotic candidates have been synthesized using this approach, a number of which are active against bacterial strains that are resistant to currently used antibiotics.

    • Ian B. Seiple
    • , Ziyang Zhang
    •  & Andrew G. Myers

  • Letter |

    Enantiospecific total synthesis of (+)-phorbol in only 19 steps from the abundant monoterpene (+)-3-carene is demonstrated using a two-phase terpene synthesis strategy.

    • Shuhei Kawamura
    • , Hang Chu
    •  & Phil S. Baran

  • Article |

    WebNetwork analysis to determine the maximally bridged ring (or rings) of molecules is used as part of a strategy for the syntheses of architecturally complex natural chemicals; this strategy is demonstrated via the synthesis of the diterpenoid alkaloids weisaconitine D and liljestrandinine.

    • C. J. Marth
    • , G. M. Gallego
    •  & R. Sarpong

  • News & Views |

    Nature crafts many molecules from common precursors, but this approach isn't always possible in chemical synthesis. A strategy for synthesizing a family of natural products succeeds by ignoring nature's blueprint. See Article p.461

    • Stéphane Quideau

  • News & Views |

    The synthesis of conolidine, a scarce, naturally occurring compound, has enabled the first studies of its pharmacological properties to be carried out. Excitingly, conolidine is a painkiller that seems to have an unusual mechanism of action.

    • Sarah E. Reisman

  • Article |

    There are a large number of chemical transformations in which alkenes act as the reactants and/or the products of the reaction, but methods enabling the facile synthesis of 1,2-disubstituted Z alkenes are scarce. This paper describes catalytic Z-selective cross-metathesis reactions of terminal enol ethers, which have not been reported previously,and allylic amides, used thus far only in E-selective processes. The utility of this methodology is demonstrated by its use in syntheses of anti oxidant C18 (plasm)-16:0 (PC), found in electrically active tissues and implicated in Alzheimer's disease, and the potent immunostimulant KRN7000.

    • Simon J. Meek
    • , Robert V. O’Brien
    •  & Amir H. Hoveyda

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