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Collagen VI regulates satellite cell self-renewal and muscle regeneration
Satellite cells have important roles in homeostasis and regeneration of skeletal muscles. Urciuolo et al. show that the extracellular matrix protein collagen VI is required for preserving satellite cell self-renewal and muscle regeneration in vitro and in vivoby modulating muscle mechanical properties.
- Anna Urciuolo
- , Marco Quarta
- & Paolo Bonaldo
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Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity
Stem cells hold great potential for therapeutic use but their supply is limited. Latilet al.isolate muscle stem cells from human and mouse cadavers after 17 and 14 days, respectively, and show that when transplanted into mice the cells can regenerate tissues.
- Mathilde Latil
- , Pierre Rocheteau
- & Fabrice Chrétien
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| Open AccessMuscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model
The function of adult stem cells is diminished with age but the role this dysfunction plays in the aging process is unknown. Here, the injection of muscle-derived stem/progenitor cells from young mice rescues symptoms in progeroid mice and is shown to regenerate tissues independent of engraftment.
- Mitra Lavasani
- , Andria R. Robinson
- & Johnny Huard