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The reaction-diffusion basis of animated patterns in eukaryotic flagella
In 1952, Turing unlocked the reaction-diffusion basis of natural patterns, such as zebra stripes. The authors propose a reaction-diffusion model that recreates characteristics of the flagellar waveform for bull sperm and Chlamydomonas flagella.
- James F. Cass
- & Hermes Bloomfield-Gadêlha
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Article
| Open Access
Conserved roles for the dynein intermediate chain and Ndel1 in assembly and activation of dynein
The mechanism by which dynein-mediated cargo transport is switched on is unresolved. This study reveals insights into the roles of the human disease genes Ndel1 and LIS1 in the assembly and activation of dynein transport complexes.
- Kyoko Okada
- , Bharat R. Iyer
- & Richard J. McKenney
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Article
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Cryo-EM structure of the folded-back state of human β-cardiac myosin
The authors report the high-resolution structure of human β-cardiac myosin in its sequestered state. The results provide insights into the cardiac regulation and represent a tool to investigate the development of inherited cardiomyopathies.
- Alessandro Grinzato
- , Daniel Auguin
- & Julien Robert-Paganin
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Article
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TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport
The mechanisms of microtubule-based mitochondrial transport remain poorly understood. Here, the authors show that the mitochondrial TRAK adaptors activate the dynein-dynactin complex, enhance the motility of kinesin, and can scaffold both motors to control bidirectional transport.
- John T. Canty
- , Andrew Hensley
- & Ahmet Yildiz
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Article
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A multi-state dynamic process confers mechano-adaptation to a biological nanomachine
Combining experiments with modeling, Wadhwa et al. propose a model for mechano-adaptation in the bacterial flagellar motor, finding that load-dependent transitions between multiple internal states govern the binding and unbinding of subunits.
- Navish Wadhwa
- , Alberto Sassi
- & Yuhai Tu
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Article
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Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors
Mitochondrial transport toward both the plus- and minus-ends of microtubules is mediated by motor proteins linked to mitochondria by TRAK adaptor proteins. Here the authors investigate the role of TRAK2 as a bidirectional motor adaptor, and propose a model where TRAK2 coordinates the activities of opposing kinesin-1 and cytoplasmic dynein motors as a single interdependent motor complex.
- Adam R. Fenton
- , Thomas A. Jongens
- & Erika L. F. Holzbaur
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Article
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A binding protein regulates myosin-7a dimerization and actin bundle assembly
Myosin-7a is found in actin bundles, microvilli and stereocilia, and plays conserved roles in hearing and vision. Here the authors identify M7BP, a myosin-7a binding protein that activates and dimerizes myosin-7a, enabling cargo transport and assembly of actin bundles and filopodia-like protrusions
- Rong Liu
- , Neil Billington
- & James R. Sellers
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Article
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Regulation of in vivo dynein force production by CDK5 and 14-3-3ε and KIAA0528
Dynein plays roles in vesicular, organelle, chromosomal and nuclear transport but so far it is unclear how dynein activity in cells is regulated. Here authors study several dynein cofactors and their role in force adaptation of dynein during lipid droplet, lysosomal, and mitochondrial transport.
- Dail E. Chapman
- , Babu J. N. Reddy
- & Steven P. Gross
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Article
| Open Access
Timing of inorganic phosphate release modulates the catalytic activity of ATP-driven rotary motor protein
The F1-ATPase is a motor protein which exhibits rotary motion as a result of catalytic hydrolysis of ATP. Here, the authors investigate how the sequence of this reaction influences molecular rotation, showing that premature product release can result in protein inactivation.
- Rikiya Watanabe
- & Hiroyuki Noji
Nde1 promotes Lis1-mediated activation of dynein