Molecular medicine articles within Nature Communications

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  • Article
    | Open Access

    The platelets detect and respond to shear stress generated by blood flow. Here the authors show that the binding of the soluble von Willebrand factor to its receptor GPIba under physiological shear stress induces receptor's domain unfolding on the platelet and signalling into the platelet, leading to platelets clearance.

    • Wei Deng
    • , Yan Xu
    •  & Renhao Li

  • Article
    | Open Access

    The inorganic procoagulant polymer polyphosphate participates in thrombosis via factor XII. Here the authors use recombinant probes that specifically bind or degrade circulating polyphosphate to protect mice in arterial and venous thrombosis models without an increased bleeding risk, the primary complication of all currently used anticoagulants.

    • Linda Labberton
    • , Ellinor Kenne
    •  & Thomas Renné

  • Article
    | Open Access

    MURC protein regulates the function of caveolae, the small invaginations of the plasma membrane in muscle cells. Here the authors show that by interacting with caveolin proteins, MURC affects RhoA/ROCK signalling and regulates proliferation and migration of pulmonary artery smooth muscle cells, suggesting a new target in therapy of pulmonary hypertension.

    • Naohiko Nakanishi
    • , Takehiro Ogata
    •  & Tomomi Ueyama

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