Article
|
Open Access
Featured
-
-
Article
| Open AccessAPOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia
A microglial state, featuring lipid droplets and secretion of neurotoxic factors, is shown to be most prominent in people with Alzheimer’s disease who have the APOE4 genotype.
- Michael S. Haney
- , Róbert Pálovics
- & Tony Wyss-Coray
-
Article
| Open AccessMicroglia regulate central nervous system myelin growth and integrity
Resident microglia in the central nervous system are identified as the specific macrophage population that regulates myelin growth and integrity.
- Niamh B. McNamara
- , David A. D. Munro
- & Veronique E. Miron
-
Article |
Prenatal immune stress blunts microglia reactivity, impairing neurocircuitry
Aberrantly formed microglia due to an adverse prenatal environment affect long-term microglia reactivity and proper striatal circuit development in mice
- Lindsay N. Hayes
- , Kyongman An
- & Akira Sawa
-
Article |
Pyramidal neuron subtype diversity governs microglia states in the neocortex
Spatial and single-cell transcriptomic characterization of microglia in the mouse somatosensory cortex show that the state of these cells is determined by signals from diverse surrounding neurons.
- Jeffrey A. Stogsdill
- , Kwanho Kim
- & Paola Arlotta
-
Article |
Microglia-organized scar-free spinal cord repair in neonatal mice
In neonatal mice, scar-free healing after spinal cord injury is organized by microglia, and transplantation of neonatal microglia or peptidase-inhibitor-treated adult microglia into adult mice after injury improves healing and axon regrowth.
- Yi Li
- , Xuelian He
- & Zhigang He
-
Article |
Negative feedback control of neuronal activity by microglia
Microglia, the brain’s immune cells, suppress neuronal activity in response to synaptic ATP release and alter behavioural responses in mice.
- Ana Badimon
- , Hayley J. Strasburger
- & Anne Schaefer
-
Article |
Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency
In the absence of progranulin, microglia enter a disease-specific state that causes endolysosomal dysfunction and neurodegeneration, and these microglia promote TDP-43 granule formation, nuclear pore defects and cell death specifically in excitatory neurons via the complement activation pathway.
- Jiasheng Zhang
- , Dmitry Velmeshev
- & Eric J. Huang
-
Letter |
Microglia-dependent synapse loss in type I interferon-mediated lupus
Abnormal behavioural phenotypes and synapse loss in the brain of lupus-prone mice are prevented by blocking type I interferon signalling, which is further shown to stimulate microglial phagocytosis of neuronal material in the brains of these mice.
- Allison R. Bialas
- , Jessy Presumey
- & Michael C. Carroll
-
Letter |
TAM receptors regulate multiple features of microglial physiology
Microglial phagocytosis is required for neurogenic niche maintenance and response to injury; the TAM kinases Mer and Axl are expressed by microglia in the adult CNS, and mediate the clearance of apoptotic cells from the niche.
- Lawrence Fourgeaud
- , Paqui G. Través
- & Greg Lemke
-
News Feature |
Microglia: The constant gardeners
Once thought to be passive sentinels, microglia now seem to be crucial for pruning back neurons during development.
- Virginia Hughes
-
News |
Nanomaterials offer hope for cerebral palsy
Rabbits with brain injuries hop again after treatment with dendrimers.
- Amy Maxmen
-
Letter |
Wild-type microglia arrest pathology in a mouse model of Rett syndrome
Transplanting bone marrow from wild-type mice into MECP2-lacking mice results in wild-type microglial engraftment, extends lifespan and reduces symptoms of disease such as breathing and locomotor abnormalities, implicating microglia in the pathophysiology of Rett syndrome.
- Noël C. Derecki
- , James C. Cronk
- & Jonathan Kipnis
-
Article |
Caspase signalling controls microglia activation and neurotoxicity
- Miguel A. Burguillos
- , Tomas Deierborg
- & Bertrand Joseph
-
Research Highlights |
Neurobiology: Trimming brain connections
-
Review Article |
The myeloid cells of the central nervous system parenchyma
- Richard M. Ransohoff
- & Astrid E. Cardona