Menopause articles within Nature Communications

Featured

• Article
  06 February 2024 | Open Access

  The impact of reproductive factors on the metabolic profile of females from menarche to menopause

  Here, the authors explore the relation between age at menarche, parity and age at natural menopause with 249 metabolic traits in over 65,000 UK Biobank to explore whether reproductive factors are likely to impact females’ metabolic profile later in life.

  • Gemma L. Clayton
  • , Maria Carolina Borges
  •  & Deborah A. Lawlor

• Article
  18 October 2023 | Open Access

  FSH and ApoE4 contribute to Alzheimer’s disease-like pathogenesis via C/EBPβ/δ-secretase in female mice

  Follicle stimulating hormone (FSH) has been shown to Alzheimer’s disease like pathology in rodent models. Here the authors show using cellular and animal models that ApoE4 and FSH collectively act to trigger AD-like pathogenesis, by activating C/EBPβ/δ-secretase signalling.

  • Jing Xiong
  • , Seong Su Kang
  •  & Keqiang Ye

• Article
  11 October 2019 | Open Access

  Rare mutations in the complement regulatory gene CSMD1 are associated with male and female infertility

  Many molecular and physiological mechanisms in the regulation of fertility are shared between female and male mammals. Here, Lee et al. report an association of CNVs in CSMD1 with early idiopathic menopause in women and show that loss of Csmd1 leads to gonadal dysfunction in both male and female mice.

  • Arthur S. Lee
  • , Jannette Rusch
  •  & Donald F. Conrad