Membrane fission articles within Nature

Featured

• Article | 27 March 2024

  The HEAT repeat protein HPO-27 is a lysosome fission factor

  The conserved HEAT repeat protein HPO-27 is identified as a lysosome scission factor in Caenorhabditis elegans, and the human homologue MROH1 also serves the same function to maintain lysosomal homeostasis.

  • Letao Li
  • , Xilu Liu
  •  & Xiaochen Wang

• Letter | 01 August 2018

  Cryo-EM of the dynamin polymer assembled on lipid membrane

  A cryo-electron microscopy structure of human dynamin-1 demonstrates conformational changes and sheds light on the fission of membranes during endocytosis.

  • Leopold Kong
  • , Kem A. Sochacki
  •  & Jenny E. Hinshaw

• Letter | 24 August 2015

  Crystal structure of the dynamin tetramer

  The crystal structure of the large GTPase dynamin tetramer is presented, suggesting a mechanism by which oligomerization of dynamin is regulated, and revealing how mutations that interfere with tetramer formation and autoinhibition are of relevance to understanding the congenital muscle disorders Charcot–Marie–Tooth neuropathy and centronuclear myopathy.

  • Thomas F. Reubold
  • , Katja Faelber
  •  & Susanne Eschenburg

• Letter | 03 July 2013

  Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate

  Phosphoinositides are important regulators of intracellular membrane traffic, and although the role of PI(4,5)P₂ has been well characterised, the function of PI(3,4)P₂ remains unclear; here the formation of PI(3,4)P₂ by the class II phosphatidylinositol-3-kinase C2α enzyme is shown to control clathrin-mediated endocytosis.

  • York Posor
  • , Marielle Eichhorn-Gruenig
  •  & Volker Haucke