News & Views |
Featured
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News |
Mid-career crunch
Some senior scientists feel neglected by the National Institutes of Health's grant formula.
- Kendall Powell
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News |
Hidden toll of embryo ethics war
Federal funds continue to be withheld for stem cells derived without destroying embryos.
- Heidi Ledford
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News Feature |
Virology: Fighting for a cause
When Judy Mikovits found links between chronic fatigue syndrome and a virus, the world took notice. Now, she's caught between the patients who believe her work and the researchers who don't.
- Ewen Callaway
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News |
European Court of Justice rejects stem-cell patents
Researchers surprised by judge's conservative stance.
- Alison Abbott
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News & Views |
Context is key in the gut
The vitamin-A metabolite retinoic acid normally favours immune tolerance in the gut. But in coeliac disease — an intestinal inflammatory disorder due to adverse reactivity to a dietary protein — it may do just the opposite. See Letter p.220
- Craig L. Maynard
- & Casey T. Weaver
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Editorial |
The generation game
Birth-cohort studies offer invaluable data on the links between childhood development and later life, but today's efforts could learn something from a pioneering project that turns 65 this week.
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News |
NIH revamp rushes ahead
Translational-science centre remains on the fast track, despite concerns about upheaval.
- Meredith Wadman
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News Feature |
Epidemiology: Study of a lifetime
In 1946, scientists started tracking thousands of British children born during one cold March week. On their 65th birthday, the study members find themselves more scientifically valuable than ever before.
- Helen Pearson
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Editorial |
Animal rights and wrongs
A Nature survey shows the pernicious impact of activism on biomedical scientists. More institutions must offer researchers the training they need to stand up for their work.
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Comment |
Animal testing: TV or not TV?
Two views on whether scientists who believe that animal experimentation is necessary should become public advocates, or work quietly behind the scenes.
- Tipu Aziz
- , John Stein
- & Ranga Yogeshwar
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News & Views |
Infectivity versus toxicity
Prions are infectious proteins that can cause deadly diseases in mammals. Detailed measurements of infectivity suggest that there may be distinct infectious and toxic versions of this protein. See Letter p.540
- Reed B. Wickner
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News & Views |
A molecular shield from trauma
Why do some people develop post-traumatic stress disorder, but others emerge from a horrific event relatively unscathed? A molecule involved in orchestrating the brain's response to stress may hold the key to this difference. See Article p.492
- Murray B. Stein
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News Feature |
Animal research: Battle scars
Nearly one-quarter of biologists say they have been affected by animal activists. A Nature poll looks at the impact.
- Daniel Cressey
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News Feature |
Animal Research: The radical
Researcher by day and activist by night, Joseph Harris was leading an untenable double life that eventually landed him in prison.
- Shanta Barley
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News |
Licence rules hinder work on rare disease
Animal model off-limits to Rett-syndrome researchers.
- Erika Check Hayden
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Books & Arts |
Genomics: Sequence sharing
Peter Border asks how we can protect our personal genomic data while making them available for research.
- Peter Border
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World View |
Pharmaceutical industry must take its medicine
To fix the drug pipeline, governments must take on drug-makers instead of capitulating to their every demand, says Colin Macilwain.
- Colin Macilwain
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Comment |
Too many roads not taken
Most protein research focuses on those known before the human genome was mapped. Work on the slew discovered since, urge Aled M. Edwards and his colleagues.
- Aled M. Edwards
- , Ruth Isserlin
- & Frank H. Yu
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News Feature |
Stem cells: The crusader
Theresa Deisher once shunned religion for science. Now, with renewed faith, she is fighting human-embryonic-stem-cell research in court.
- Meredith Wadman
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Perspective |
Charting a course for genomic medicine from base pairs to bedside
- Eric D. Green
- , Mark S. Guyer
- & Jane L. Peterson
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News |
Options for off-the-shelf blood vessels expand
Preliminary research could open the door to ready-to-use bioengineered veins.
- Tiffany O’Callaghan
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News |
Flaw in induced-stem-cell model
Adult cells do not fully convert to embryonic-like state.
- Elie Dolgin
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News & Views |
Diabetes in India
With the spread of fast-food outlets and more sedentary lifestyles, the prevalence of diabetes in India is rising alarmingly. But the subpopulations at risk and the symptoms of the disease differ from those in the West.
- Jared Diamond
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Correspondence |
Cutting random funding decisions
- Nicholas Graves
- , Adrian G. Barnett
- & Philip Clarke
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News |
France mulls embryo research reform
Scientists and clinicians push for a clearer, more permissive law on human embryonic stem-cell work.
- Declan Butler
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News |
Cells snag top modelling job
Heart disorder joins growing list of conditions getting the 'disease in a dish' treatment.
- Ewen Callaway
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Comment |
Bring on the biomarkers
The dismal patchwork of fragmented research on disease-associated biomarkers should be replaced by a coordinated 'big science' approach, argues George Poste.
- George Poste
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News |
Cancer trial errors revealed
University officials admit data withheld from review panel before misconduct charges arose.
- Eugenie Samuel Reich
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News |
UK health research to be rehabilitated
Government welcomes report on reform of 'complex and scattered' regulation.
- Daniel Cressey
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News |
From battlefield to bedside
Medical research in the British military soldiers on despite defence cuts.
- Daniel Cressey
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World View |
Drug development needs a new brand of science
We need to break with the past to develop new medicines, says Garret FitzGerald. An interdisciplinary NIH centre points the way.
- Garret FitzGerald
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News |
Slim spoils for obesity drugs
Drug makers struggle to find viable treatments for global epidemic.
- Heidi Ledford
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News Q&A |
The bridge between lab and clinic
Francis Collins makes the case for an institute focused on translational research.
- Meredith Wadman
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Career Brief |
Biomedical recruitment
Irish partnership gets €19-million government grant for diagnostics R&D.
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Editorial |
Animal instinct
Germany must better explain the scientific use of animals to remain a major biomedical force.
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News |
NIH director wins bid for translational medicine centre
New nexus will bridge basic and clinical research to improve health.
- Meredith Wadman
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News Feature |
Stem cells: The impatient advocate
Bob Klein founded the California Institute for Regenerative Medicine, the biggest state-run research project in US history. What legacy will he leave behind?
- Elie Dolgin
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Editorial |
Treated fairly?
Moves to price new pharmaceuticals sensibly shouldn't damage the industry's health.
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News |
High hopes for arthritis drugs
Race is on to develop treatments that inhibit signalling proteins.
- Heidi Ledford
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Q&A |
Turning point: Jacob Hanna
Palestinian researcher heads to Israel to foster scientific exchange.
- Virginia Gewin
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Perspective |
From maps to mechanisms through neuroimaging of schizophrenia
- Andreas Meyer-Lindenberg