Measles virus articles within Nature Communications

Featured

• Article
  08 February 2024 | Open Access

  Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets

  Measles virus infection causes immunosuppression and it’s unclear whether this can be prevented by antivirals. Here, using a canine distemper virus ferret model, the authors show that measles-like immune amnesia and lethal exacerbated respiratory disease after consecutive respiratory virus infections can be mitigated by oral antiviral therapy initiated at the onset of primary clinical signs.

  • Robert M. Cox
  • , Josef D. Wolf
  •  & Richard K. Plemper

• Article
  29 March 2023 | Open Access

  Long-term measles antibody profiles following different vaccine schedules in China, a longitudinal study

  The timing of measles vaccination in infants affects the risk of infection in young children and the duration of protection provided. Here, the authors investigate optimal vaccination timing by characterising antibody kinetics following different vaccine schedules in two cohorts of children in southern China.

  • Qianli Wang
  • , Wei Wang
  •  & Hongjie Yu

• Article
  28 October 2022 | Open Access

  Nebulized fusion inhibitory peptide protects cynomolgus macaques from measles virus infection

  Despite the availability of a safe and effective vaccine, measles remains the leading cause of child death among vaccine-preventable diseases. In this work, authors utilised a cynomolgus macaque model of infection, and a mesh nebuliser administration approach, to show efficacy of their aerosolized lipopeptide fusion inhibitor against the measles virus.

  • Olivier Reynard
  • , Claudia Gonzalez
  •  & Branka Horvat

• Article
  02 September 2021 | Open Access

  Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding

  Measles virus is highly contagious and outbreaks occur worldwide. Here the authors show that the orally bioavailable small-molecule polymerase inhibitor ERDRP-0519 prevents measles disease in squirrel monkeys and reduces virus shedding.

  • Kevin Wittwer
  • , Danielle E. Anderson
  •  & Veronika von Messling

• Article
  23 November 2018 | Open Access

  Studies into the mechanism of measles-associated immune suppression during a measles outbreak in the Netherlands

  The mechanisms by which measles virus infection induces transient immune suppression in humans are poorly understood. Here, Laksono and colleagues characterise the pathogenesis of measles-associated immune suppression in unvaccinated children, and shed new light on the long-term effects of measles on the host.

  • Brigitta M. Laksono
  • , Rory D. de Vries
  •  & Rik L. de Swart

• Article
  30 April 2018 | Open Access

  Promotion of virus assembly and organization by the measles virus matrix protein

  Virus assembly is technically challenging to study. Here the authors use cryo-electron tomography of measles virus-infected human cells to determine native-state virus structure and they locate well-ordered M lattices that organize viral glycoproteins, RNP, and drive assembly.

  • Zunlong Ke
  • , Joshua D. Strauss
  •  & Elizabeth R. Wright

• Article
  25 May 2017 | Open Access

  The geography of measles vaccination in the African Great Lakes region

  The WHO targets measles elimination by 2020, a goal that relies on high vaccination coverage. Here, Takahashiet al. identify ‘coldspots’ in the African Great Lakes region where measles vaccine coverage is below 80%, suggesting that these regions should be targeted in future vaccination campaigns.

  • Saki Takahashi
  • , C. Jessica E. Metcalf
  •  & Justin Lessler