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| Open AccessMachine learning the dimension of a Fano variety
Fano varieties are mathematical shapes that are basic units in geometry, they are challenging to classify in high dimensions. The authors introduce a machine learning approach that picks out geometric structure from complex mathematical data where rigorous analytical methods are lacking.
- Tom Coates
- , Alexander M. Kasprzyk
- & Sara Veneziale
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Article
| Open AccessHeterogeneity in M. tuberculosis β-lactamase inhibition by Sulbactam
Here, the reaction of the suicide inhibitor sulbactam with the M. tuberculosis β-lactamase (BlaC) is investigated with time-resolved crystallography. Singular Value Decomposition is implemented to extract kinetic information despite changes in unit cell parameters during the time-course of the reaction.
- Tek Narsingh Malla
- , Kara Zielinski
- & Marius Schmidt
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Article
| Open AccessDemonstration of an AI-driven workflow for autonomous high-resolution scanning microscopy
Modern microscopes can image a sample with sub-Angstrom and sub-picosecond resolutions, but this often requires analysis of tremendously large datasets. Here, the authors demonstrate that an autonomous experiment can yield over a 70% reduction in dataset size while still producing high-fidelity images of the sample.
- Saugat Kandel
- , Tao Zhou
- & Mathew J. Cherukara
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Article
| Open AccessA deep learning-based stripe self-correction method for stitched microscopic images
Image stitching in fluorescence microscopy can be a hindrance to image quality and to downstream quantitative analyses. Here, the authors propose a deep learning-based stripe self-correction method that corrects diverse stripes and artifacts for stitched microscopic images.
- Shu Wang
- , Xiaoxiang Liu
- & Jianxin Chen
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Article
| Open AccessSynthesize high-dimensional longitudinal electronic health records via hierarchical autoregressive language model
The paper presents HALO, a Hierarchical Autoregressive Language Model, for generating high-fidelity, longitudinal electronic health records (EHR) data. HALO maintains statistical property, supports machine learning modeling without privacy concerns.
- Brandon Theodorou
- , Cao Xiao
- & Jimeng Sun
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Article
| Open AccessHardware-aware training for large-scale and diverse deep learning inference workloads using in-memory computing-based accelerators
Analog in-memory computing promises efficient DNN inference acceleration but suffers from nonidealities. Here, hardware-aware training methods are improved so that various larger DNNs of diverse topologies nevertheless achieve iso-accuracy.
- Malte J. Rasch
- , Charles Mackin
- & Vijay Narayanan
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Article
| Open AccessCritical dynamics arise during structured information presentation within embodied in vitro neuronal networks
The conditions under which networks of neurons exhibit critical dynamics remains unclear. Here, the authors investigate how simple neural cultures reorganize activity when embodied in a gameplay environment and find that network wide neural criticality arises in nuanced ways.
- Forough Habibollahi
- , Brett J. Kagan
- & Chris French
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Article
| Open AccessSecurity of quantum key distribution from generalised entropy accumulation
Security proofs against general attacks are the ultimate goal of QKD. Here, the authors show how the Generalised Entropy Accumulation Theorem can be used, for some classes of QKD scenarios, to translate security proofs against collective attacks in the asymptotic regime into proofs against general attacks in the finite-size regime.
- Tony Metger
- & Renato Renner
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Article
| Open AccessUniversal patterns in egocentric communication networks
Personal communication networks through mobile phones and online platforms can be characterized by patterns of tie strengths. The authors propose a model to explain driving mechanisms of emerging tie strength heterogeneity in social networks, observing similarity of patterns across various datasets.
- Gerardo Iñiguez
- , Sara Heydari
- & Jari Saramäki
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Article
| Open AccessProjecting RNA measurements onto single cell atlases to extract cell type-specific expression profiles using scProjection
Many expression deconvolution approaches have been developed to estimate % RNA contributions of diverse cell types to mixed RNA measurements. Here, the authors have developed a complementary approach called scProjection to recover cell type-specific expression profiles from mixed RNA measurements.
- Nelson Johansen
- , Hongru Hu
- & Gerald Quon
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Article
| Open AccessPropensity of selecting mutant parasites for the antimalarial drug cabamiquine
Authors utilize a number of models (mathematical, in vitro and in vivo infection) to analyse pre-clinical and Phase I clinical trial data, in regard to potential risk of resistance associated with a Plasmodium falciparum inhibitor, cabamiquine.
- Eva Stadler
- , Mohamed Maiga
- & Thomas Spangenberg
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Article
| Open AccessIn-memory mechanical computing
Here, Mei and Chen propose an in-memory mechanical computing architecture with simplified and reduced data exchange, where computing occurs within mechanical memory units, to facilitate the design of intelligent mechanical systems.
- Tie Mei
- & Chang Qing Chen
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Article
| Open AccessZero-shot visual reasoning through probabilistic analogical mapping
Inspired by human analogical reasoning in cognitive science, the authors propose an approach combining deep learning systems with an analogical reasoning mechanism, to detect abstract similarity in real-world images without intensive training in reasoning tasks.
- Taylor Webb
- , Shuhao Fu
- & Hongjing Lu
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Article
| Open AccessSequence anticipation and spike-timing-dependent plasticity emerge from a predictive learning rule
Prediction of future inputs is a key computational task for the brain. Here, the authors proposed a predictive learning rule in neurons that leads to anticipation and recall of inputs, and that reproduces experimentally observed STDP phenomena.
- Matteo Saponati
- & Martin Vinck
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Article
| Open AccessA deep learning method for replicate-based analysis of chromosome conformation contacts using Siamese neural networks
Siamese neural networks are a powerful deep learning approach for image analysis. Here, the authors adapt this method to the replicate-based analysis of Hi-C data and find that it successfully discriminates technical noise from biological variation.
- Ediem Al-jibury
- , James W. D. King
- & Daniel Rueckert
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Article
| Open AccessGeospatial mapping of distribution grid with machine learning and publicly-accessible multi-modal data
Granular geospatial information of distribution grids is needed for various power system applications. Here the authors develop a machine-learning-based model which can accurately map distribution grids in both the U.S. and Sub-Saharan Africa.
- Zhecheng Wang
- , Arun Majumdar
- & Ram Rajagopal
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Comment
| Open AccessThe brain’s unique take on algorithms
The current gap between computing algorithms and neuromorphic hardware to emulate brains is an outstanding bottleneck in developing neural computing technologies. Aimone and Parekh discuss the possibility of bridging this gap using theoretical computing frameworks from a neuroscience perspective.
- James B. Aimone
- & Ojas Parekh
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Perspective
| Open AccessToward a formal theory for computing machines made out of whatever physics offers
Learning from human brains to build powerful computers is attractive, yet extremely challenging due to the lack of a guiding computing theory. Jaeger et al. give a perspective on a bottom-up approach to engineer unconventional computing systems, which is fundamentally different to the classical theory based on Turing machines.
- Herbert Jaeger
- , Beatriz Noheda
- & Wilfred G. van der Wiel
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Article
| Open AccessCOMPASS: joint copy number and mutation phylogeny reconstruction from amplicon single-cell sequencing data
Understanding the evolution of a tumor is important for predicting its resistance to treatment. This paper presents a new computational method, COMPASS, for inferring the joint phylogeny of single nucleotide variants and copy number alterations from targeted scDNAseq data.
- Etienne Sollier
- , Jack Kuipers
- & Katharina Jahn
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Article
| Open AccessDeep-learning based detection of vessel occlusions on CT-angiography in patients with suspected acute ischemic stroke
AI may enhance diagnostic accuracy in medicine. Here, authors developed an AI model to detect and localise vessel occlusions in patients with suspected ischemic stroke, outperforming commercial tools on pseudo-prospective multicenter benchmarking.
- Gianluca Brugnara
- , Michael Baumgartner
- & Philipp Vollmuth
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Article
| Open AccessSubtle adversarial image manipulations influence both human and machine perception
Artificial neural networks (ANNs) are vulnerable to subtle adversarial perturbations that yield misclassification errors. Here, behavioral studies demonstrate that adversarial perturbations that fool ANNs similarly bias human choice.
- Vijay Veerabadran
- , Josh Goldman
- & Gamaleldin F. Elsayed
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Perspective
| Open AccessApplied machine learning as a driver for polymeric biomaterials design
The design of polymers for regenerative medicine could be accelerated with the help of machine learning. Here the authors note that machine learning has been applied successfully in other areas of polymer chemistry, while highlighting that data limitations must be overcome to enable widespread adoption within polymeric biomaterials.
- Samantha M. McDonald
- , Emily K. Augustine
- & Matthew L. Becker
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Article
| Open AccessGenomic epidemiology offers high resolution estimates of serial intervals for COVID-19
The serial interval (time between symptom onset in an infector and infectee) is usually estimated from contact tracing data, but this is not always available. Here, the authors develop a method for estimation of serial intervals using whole genome sequencing data and apply it data from clusters of SARS-CoV-2 in Victoria, Australia.
- Jessica E. Stockdale
- , Kurnia Susvitasari
- & Caroline Colijn
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Article
| Open AccessCell-type-specific co-expression inference from single cell RNA-sequencing data
Inferring co-expressions with scRNA-seq data is challenging, and existing methods suffer from inflated false positives and biases. Here, the authors proposed CS-CORE, which yields unbiased estimates and identifies co-expressions that are more reproducible and biologically relevant for scRNA-seq data.
- Chang Su
- , Zichun Xu
- & Jingfei Zhang
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Article
| Open AccessDiscovering conservation laws using optimal transport and manifold learning
Conservation laws are crucial for analyzing and modeling nonlinear dynamical systems; however, identification of conserved quantities is often quite challenging. The authors propose here a geometric approach to discovering conservation laws directly from trajectory data that does not require an explicit dynamical model of the system or detailed time information.
- Peter Y. Lu
- , Rumen Dangovski
- & Marin Soljačić
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Article
| Open AccessSONAR enables cell type deconvolution with spatially weighted Poisson-Gamma model for spatial transcriptomics
Spatial transcriptomics reveal cellular profiles with spatial context. Here the authors present SONAR, a computational model that utilizes spatial information to decipher cell types in tissues and validate on various spatial patterns and fine-mapped cell types in complex tissues.
- Zhiyuan Liu
- , Dafei Wu
- & Liang Ma
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Article
| Open AccessNeural network-based Bluetooth synchronization of multiple wearable devices
Synchronization of e-wearables can be challenging due to device performance variations. Here, the authors develop a general neural network-based solution that analyses and correct disparities between multiple virtual clocks and demonstrate it for a Bluetooth synchronized motion capture system at high frequency.
- Karthikeyan Kalyanasundaram Balasubramanian
- , Andrea Merello
- & Marco Crepaldi
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Article
| Open AccessWarning of a forthcoming collapse of the Atlantic meridional overturning circulation
The Atlantic meridional overturning circulation (AMOC) is a major tipping element in the climate system. Here, data-driven estimators for the time of tipping predict a potential AMOC collapse mid-century under the current emission scenario.
- Peter Ditlevsen
- & Susanne Ditlevsen
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Article
| Open AccessA general model-based causal inference method overcomes the curse of synchrony and indirect effect
Traditional causal inference methods struggle to distinguish direct causation from synchrony and indirect effects. Here, authors present GOBI that overcomes this by testing a general model’s ability to reproduce data, providing accurate and broadly applicable causality inference for complex systems.
- Se Ho Park
- , Seokmin Ha
- & Jae Kyoung Kim
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Article
| Open AccessComputational analysis of peripheral blood smears detects disease-associated cytomorphologies
While experts analyze cytomorphology to diagnose myelodysplastic syndromes, definitive diagnosis requires complementary information such as karyotype and molecular genetics testing. Here, the authors present a computational method that automatically detects, characterizes and helps identify blood cell characteristics associated with this group of diseases.
- José Guilherme de Almeida
- , Emma Gudgin
- & Moritz Gerstung
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Article
| Open AccessDetecting shortcut learning for fair medical AI using shortcut testing
Diagnosing shortcut learning in clinical models is difficult, as sensitive attributes may be causally linked with disease. Using multitask learning, the authors propose a method to directly test for the presence of shortcut learning in clinical ML systems.
- Alexander Brown
- , Nenad Tomasev
- & Jessica Schrouff
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Article
| Open AccessCoherent movement of error-prone individuals through mechanical coupling
In biology, individuals are known to achieve higher navigation accuracy when moving in a group compared to single animals. The authors show that simple self-propelled robotic modules that are incapable of accurate motion as individuals can achieve accurate group navigation once coupled via deformable elastic links.
- Federico Pratissoli
- , Andreagiovanni Reina
- & Roderich Groß
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Article
| Open AccessAtlas-scale single-cell multi-sample multi-condition data integration using scMerge2
Recent advances in multi-condition single-cell multi-cohort studies enable exploration of diverse cell states. Here, authors present scMerge2, an algorithm that allows integration of a large COVID-19 data collection with over five million cells to uncover distinct signatures of disease progression.
- Yingxin Lin
- , Yue Cao
- & Jean Y. H. Yang
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Article
| Open AccessFinding defects in glasses through machine learning
Rare quantum tunneling two-level systems are known to govern the glass physics at low temperatures, but it remains challenging to detect them in simulations. Ciarella et al. show a machine learning approach to efficiently identify the structural defects, allowing to predict the quantum splitting.
- Simone Ciarella
- , Dmytro Khomenko
- & Francesco Zamponi
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Article
| Open AccessThe effect of environmental information on evolution of cooperation in stochastic games
In stochastic games, there is a feedback loop between a group’s social behaviors and its environment. Kleshnina et al. show that groups are often more cooperative when they know the exact state of their environment, although there are also intriguing cases when ignorance is beneficial.
- Maria Kleshnina
- , Christian Hilbe
- & Martin A. Nowak
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Article
| Open AccesspolyBERT: a chemical language model to enable fully machine-driven ultrafast polymer informatics
The polymer universe is gigantic. Searching this space effectively requires ultrafast high-fidelity property prediction methods. Here, the authors present a chemical language model that can probe this space at unprecedented speed and accuracy.
- Christopher Kuenneth
- & Rampi Ramprasad
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Article
| Open AccessnnSVG for the scalable identification of spatially variable genes using nearest-neighbor Gaussian processes
The identification of top spatially variable genes is a key step in the analysis of spatially-resolved transcriptomics data. Here, the authors develop a scalable method based on nearest-neighbor Gaussian processes and evaluate performance compared to existing and baseline methods.
- Lukas M. Weber
- , Arkajyoti Saha
- & Stephanie C. Hicks
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Article
| Open AccessLeveraging spatial transcriptomics data to recover cell locations in single-cell RNA-seq with CeLEry
Cell location information is important for understanding how tissue is spatially organized. Here, the authors develop CeLEry, a machine learning method that aims to recover cell locations for single-cell RNA-seq data by leveraging information learned from spatial transcriptomics.
- Qihuang Zhang
- , Shunzhou Jiang
- & Mingyao Li
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Article
| Open AccessOut-of-distribution generalization for learning quantum dynamics
Generalization - that is, the ability to extrapolate from training data to unseen data - is fundamental in machine learning, and thus also for quantum ML. Here, the authors show that QML algorithms are able to generalise the training they had on a specific distribution and learn over different distributions.
- Matthias C. Caro
- , Hsin-Yuan Huang
- & Zoë Holmes
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Article
| Open AccessAccelerating the prediction and discovery of peptide hydrogels with human-in-the-loop
Accurate prediction of peptidic hydrogels could prove useful for diverse biomedical applications. Here, the authors develop a “human-in-the-loop” approach that integrates coarse-grained molecular dynamics, machine learning, and experimentation to design natural peptide hydrogels.
- Tengyan Xu
- , Jiaqi Wang
- & Huaimin Wang
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Article
| Open AccessCAJAL enables analysis and integration of single-cell morphological data using metric geometry
Cell morphology is one of the most described phenotypes in biology, yet systematic quantification and classification of morphology remains limited. Here, the authors present a computational approach for cell morphometry and multi-modal analysis based on concepts from metric geometry.
- Kiya W. Govek
- , Patrick Nicodemus
- & Pablo G. Camara
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Article
| Open AccessWaves traveling over a map of visual space can ignite short-term predictions of sensory input
Waves of neural activity travel across single regions in the visual cortex, but their computational role is unclear. Here, the authors present a neural network model demonstrating that waves traveling over retinotopic maps can enable short-term predictions of future inputs.
- Gabriel B. Benigno
- , Roberto C. Budzinski
- & Lyle Muller
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Article
| Open AccessInflationary theory of branching morphogenesis in the mouse salivary gland
The authors show that the ramified ductal network of the mouse salivary gland develops from a set of simple probabilistic rules, where ductal elongation and branching are driven by the persistent expansion of the surrounding tissue.
- Ignacio Bordeu
- , Lemonia Chatzeli
- & Benjamin D. Simons
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Article
| Open AccessNon-line-of-sight imaging with arbitrary illumination and detection pattern
The authors propose a confocal complemented signal-object collaborative regularization method for non-line-of-sight (NLOS) imaging without specific requirements on the spatial pattern of measurement points. The method extends the application range of NLOS imaging.
- Xintong Liu
- , Jianyu Wang
- & Lingyun Qiu
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Article
| Open AccessCASPI: collaborative photon processing for active single-photon imaging
The sparse, noisy, and distorted raw photon data captured by single-photon cameras make it difficult to estimate scene properties under challenging illumination conditions. Here, the authors present Collaborative photon processing for Active Single-Photon Imaging (CASPI), a technology-agnostic, application-agnostic, and training-free photon processing pipeline for high-resolution single-photon cameras.
- Jongho Lee
- , Atul Ingle
- & Mohit Gupta
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Article
| Open AccessData-driven direct diagnosis of Li-ion batteries connected to photovoltaics
Li-ion batteries are used to store energy harvested from photovoltaics. However, battery use is sporadic and standard diagnostic methods cannot be applied. Here, the authors propose a methodology for diagnosing photovoltaics-connected Li-ion batteries that use trained machine learning algorithms.
- Matthieu Dubarry
- , Nahuel Costa
- & Dax Matthews
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Article
| Open AccessRetention time prediction for chromatographic enantioseparation by quantile geometry-enhanced graph neural network
Chromatographic enantioseparation requires tedious trials to find proper experimental conditions. Here, the authors construct a deep learning model to predict retention times of chiral molecules and obtain the separation probability under given conditions.
- Hao Xu
- , Jinglong Lin
- & Fanyang Mo
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Article
| Open AccessEvidence-driven spatiotemporal COVID-19 hospitalization prediction with Ising dynamics
Amid the COVID-19 pandemic, accurate hospitalization predictions are vital. Here, the authors show that a deep learning model based on statistical mechanics is able to forecast hospitalizations, supporting targeted vaccination efforts.
- Junyi Gao
- , Joerg Heintz
- & Jimeng Sun
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Article
| Open AccessInference of cell type-specific gene regulatory networks on cell lineages from single cell omic datasets
Cell type-specific gene expression patterns are outputs of transcriptional gene regulatory networks (GRNs) that connect transcription factors and signaling proteins to target genes. Here, the authors present single-cell Multi-Task Network Inference (scMTNI), a multi-task learning framework to infer cell type-specific GRN dynamics from scRNA-seq and scATAC-seq datasets collected for diverse cell fate specification trajectories.
- Shilu Zhang
- , Saptarshi Pyne
- & Sushmita Roy