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| Open AccessIdentification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections
Host factors involved in filovirus infection are incompletely understood. Here, the authors used a haploid cell screening system to unveil CCZ1’s crucial role in regulating endosomal trafficking thus virus movement within cells and thereby impacting Marburg and Ebola infection.
- Vanessa Monteil
- , Hyesoo Kwon
- & Ali Mirazimi
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Article
| Open AccessStructural insight into Marburg virus nucleoprotein–RNA complex formation
Marburg virus causes severe hemorrhagic fever in humans. Here, the authors determine the structure of Marburg virus nucleoprotein–RNA complex by cryo-electron microscopy and provide mechanistic insight into the helical assembly of the nucleocapsid.
- Yoko Fujita-Fujiharu
- , Yukihiko Sugita
- & Takeshi Noda
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Article
| Open AccessPost-exposure immunotherapy for two ebolaviruses and Marburg virus in nonhuman primates
Current experimental monoclonal antibodies (mAbs) for Ebola virus (EBOV) post-exposure immunotherapy are ineffective against Sudan (SUDV) or Marburg virus (MARV). Here, authors develop cocktails of mAbs that protect nonhuman primates against EBOV, SUDV, and MARV infection when given four days post infection.
- Jennifer M. Brannan
- , Shihua He
- & M. Javad Aman
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Article
| Open AccessModelling filovirus maintenance in nature by experimental transmission of Marburg virus between Egyptian rousette bats
Bats are natural hosts for Marburg virus (MARV), but the mechanism of bat-to-bat transmission is unclear. Here, Schuhet al. monitor MARV infection in a cohort of 38 bats over nine months, find ‘supershedders’ and show that MARV can horizontally transmit between bats.
- Amy J. Schuh
- , Brian R. Amman
- & Jonathan S. Towner