Macroautophagy articles within Nature

Featured

  • Article
    | Open Access

    A proteomics analysis demonstrates that, during nutrient stress, mammalian cells prioritize degradation by autophagy of membrane proteins and identifies receptors that mediate this process at the Golgi and also have a role in Golgi remodelling during neuronal differentiation.

    • Kelsey L. Hickey
    • , Sharan Swarup
    •  & J. Wade Harper

  • Letter |

    Phosphorylation of one of two adjacent serine residues in TSC2 is both required and sufficient for PKG1-mediated cardiac protection against pressure overload in mice; these serine residues provide a genetic tool for the bidirectional regulation of stress-stimulated mTORC1 activity.

    • Mark J. Ranek
    • , Kristen M. Kokkonen-Simon
    •  & David A. Kass

  • Letter |

    Mice with whole-body or liver-specific deletion of Atg7 release circulating arginase I and have reduced levels of serum arginine, which impairs the growth of allografted arginine-auxotrophic tumours.

    • Laura Poillet-Perez
    • , Xiaoqi Xie
    •  & Eileen White

  • Letter |

    The polyglutamine domain in ataxin 3, which is expanded in spinocerebellar ataxia type 3, allows normal ataxin 3 to interact with and deubiquitinate beclin 1 and thereby to promote autophagy.

    • Avraham Ashkenazi
    • , Carla F. Bento
    •  & David C. Rubinsztein

  • Letter |

    During early-stage tumour growth in Drosphila, tumour cells acquire necessary nutrients by triggering autophagy in surrounding cells in the tumour microenvironment.

    • Nadja S. Katheder
    • , Rojyar Khezri
    •  & Tor Erik Rusten

  • Letter |

    In response to cancer-associated stress, autophagy machinery mediates degradation of nuclear lamina components in mammals, suggesting that cells might degrade nuclear components to prevent tumorigenesis.

    • Zhixun Dou
    • , Caiyue Xu
    •  & Shelley L. Berger

  • Letter |

    In yeast, the novel protein Atg40 is enriched in the cortical and cytoplasmic endoplasmic reticulum (ER), and loads these ER subdomains into autophagosomes to facilitate ER autophagy; Atg39 localizes to the perinuclear ER and induces autophagic sequestration of part of the nucleus, thus ensuring cell survival under nitrogen-deprived conditions.

    • Keisuke Mochida
    • , Yu Oikawa
    •  & Hitoshi Nakatogawa

  • Article |

    The Crohn’s disease risk-conferring T300A variant in the autophagy protein ATG16L1 increases its sensitivity to caspase-3-mediated cleavage; this decreases the induction of autophagy in response to metabolic stress or pathogen infection, leading to increased secretion of inflammatory cytokines.

    • Aditya Murthy
    • , Yun Li
    •  & Menno van Lookeren Campagne

  • Article |

    The primary cilium is a microtubule-based organelle that functions in sensory and signal transduction; here the authors show that the primary cilium is required for activation of starvation-induced autophagy and that basal autophagy negatively regulates ciliogenesis.

    • Olatz Pampliega
    • , Idil Orhon
    •  & Ana Maria Cuervo

  • Letter |

    The primary cilium is a microtubule-based organelle that functions in sensory and signal transduction; the authors demonstrate here that autophagic degradation of the oral-facial-digital syndrome 1 (OFD1) protein at centriolar satellites promotes primary cilium biogenesis, and that autophagy modulation might provide a novel means of ciliopathy treatment.

    • Zaiming Tang
    • , Mary Grace Lin
    •  & Qing Zhong

  • Letter |

    This study shows that autophagosomes form at sites of contact between the endoplasmic reticulum and mitochondria, and that formation requires the SNARE protein syntaxin 17.

    • Maho Hamasaki
    • , Nobumichi Furuta
    •  & Tamotsu Yoshimori

  • Article |

    A cell-permeable peptide is constructed that is derived from a region of an essential autophagy protein called beclin 1; the peptide is a potent inducer of autophagy in mammalian cells and in vivo in mice, and is effective in the clearance of several viruses.

    • Sanae Shoji-Kawata
    • , Rhea Sumpter
    •  & Beth Levine

  • News & Views |

    Defects in mitochondria are implicated in Parkinson's disease. Study of a quality-control pathway involving the proteins PINK1 and Parkin provides further clues about the mechanism involved.

    • Asa Abeliovich

Browse broader subjects

Browse Macroautophagy across other nature.com journals