Featured
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CLN3 is required for the clearance of glycerophosphodiesters from lysosomes
The lysosomal transmembrane protein CLN3 is required for the lysosomal clearance of glycerophosphodiesters in mice and in human cells, suggesting that the loss of CLN3 causes Batten disease in children due to defects in glycerophospholipid metabolism.
- Nouf N. Laqtom
- , Wentao Dong
- & Monther Abu-Remaileh
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Article |
A phosphoinositide signalling pathway mediates rapid lysosomal repair
Lysosomal membrane damage triggers a lipid signalling pathway that repairs lysosomes via lipid transport at newly established endoplasmic reticulum–lysosomal membrane contact sites.
- Jay Xiaojun Tan
- & Toren Finkel
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Article |
Lysosome-targeting chimaeras for degradation of extracellular proteins
Lysosome-targeting chimaeras—in which a small molecule or antibody is connected to a glycopeptide ligand to form a conjugate that can bind a cell-surface lysosome-shuttling receptor and a protein target—are used to achieve the targeted degradation of extracellular and membrane proteins.
- Steven M. Banik
- , Kayvon Pedram
- & Carolyn R. Bertozzi
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Article |
ATP13A2 deficiency disrupts lysosomal polyamine export
The lysosomal polyamine transporter ATP13A2 controls the cellular polyamine content, and impaired lysosomal polyamine export represents a lysosome-dependent cell death pathway that may be implicated in ATP13A2-associated neurodegeneration.
- Sarah van Veen
- , Shaun Martin
- & Peter Vangheluwe
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Letter |
Asymmetric lysosome inheritance predicts activation of haematopoietic stem cells
The cellular degradative machinery can be asymmetrically inherited upon haematopoietic-stem-cell division, which predicts the future metabolic and translational activation of their daughter cells.
- Dirk Loeffler
- , Arne Wehling
- & Timm Schroeder
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Letter |
Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis
Formation of inter-organelle contacts between mitochondria and lysosomes, regulated by lysosomal RAB7 GTP hydrolysis, allows for bidirectional regulation of mitochondrial and lysosomal dynamics.
- Yvette C. Wong
- , Daniel Ysselstein
- & Dimitri Krainc
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Letter |
A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage
Sperm-activated lysosomes enhance proteostasis in nematode oocytes just before fertilization; this could prevent transmission of damaged proteins to the next generation and may explain the immortality of the germ-cell lineage.
- K. Adam Bohnert
- & Cynthia Kenyon
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Letter |
An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast
Vacuolar acidity in yeast is shown to decline with age, and preventing this decrease suppresses mitochondrial dysfunction and extends the lifespan of yeast.
- Adam L. Hughes
- & Daniel E. Gottschling
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Letter |
Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology
Heat shock protein 70 (Hsp70) is a molecular chaperone which, by inhibiting lysosomal membrane permeabilization, promotes the survival of stressed cells. Hsp70 is now shown to stabilize lysosomes by binding to an anionic phospholipid, BMP, resulting in stimulation of acid sphingomyelinase (ASM) activity. Notably, the decreased ASM activity and lysosomal stability seen in patients with Niemann–Pick disease can be corrected by treatment with recombinant Hsp70.
- Thomas Kirkegaard
- , Anke G. Roth
- & Marja Jäättelä