Lymphoproliferative disorders articles within Nature Communications

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• Article
  19 May 2022 | Open Access

  The phosphatase PTEN links platelets with immune regulatory functions of mouse T follicular helper cells

  Platelets have been shown to alter immune cell function but it is not clear if this includes autoimmunity. Here the authors show that phosphatase and tensin homolog (PTEN) deficient platelets promote autoimmunity in mouse models through excessive activation of T_FH cells and systemic autoimmune pathology.

  • Xue Chen
  • , Yanyan Xu
  •  & Junling Liu

• Article
  01 May 2019 | Open Access

  Loss of TET2 and TET3 in regulatory T cells unleashes effector function

  Loss of TET proteins in immune cell populations is known to result in immunopathology. Here the authors show that deficiency of Tet2 and Tet3 proteins, specifically in the CD4⁺ FoxP3⁺ Treg lineage, results in a dominant pathology in which ex-Treg cells and bystander T cells gain aberrant effector function.

  • Xiaojing Yue
  • , Chan-Wang J. Lio
  •  & Anjana Rao