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Article
| Open Access
Coincidence of cholinergic pauses, dopaminergic activation and depolarisation of spiny projection neurons drives synaptic plasticity in the striatum
It remains unclear how corticostriatal synapses utilize reward prediction error signaling in order to reinforce reward-related behaviors. Here, the authors show that potentiation of corticostriatal synapses requires phasic dopamine activation, pauses in striatal cholinergic interneuron firing, and depolarization of spiny projection neurons.
- John N. J. Reynolds
- , Riccardo Avvisati
- & Yan-Feng Zhang
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Article
| Open Access
Functional and molecular characterization of a non-human primate model of autism spectrum disorder shows similarity with the human disease
Non-human primate models of autism spectrum disorder (ASD) are few and not well characterised. Here, the authors describe synaptic function and gene expression changes in a marmoset model of ASD from birth to juvenile, highlighting its similarity to features observed in human ASD.
- Satoshi Watanabe
- , Tohru Kurotani
- & Noritaka Ichinohe
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Article
| Open Access
NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95
Long-term depression (LTD) of synaptic strength contributes to circuit remodeling, memory encoding and erasure. Here, the authors show that P2XR- and NMDAR-dependent LTD are associated with distinct and precise molecular modifications that lead to specific modification of synapse function.
- Benjamin Compans
- , Come Camus
- & Eric Hosy
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Article
| Open Access
LTD is involved in the formation and maintenance of rat hippocampal CA1 place-cell fields
LTP and LTD are involved in shaping hippocampal place field representations. Here, the authors show that de novo pathway-specific hippocampal LTD changes dynamics and stability of newly formed place fields, regulating acquisition and maintenance of novel spatial information in adult rats.
- Donovan M. Ashby
- , Stan B. Floresco
- & Yu Tian Wang
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Article
| Open Access
Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling
Caspase-2 is constitutively expressed in neurons yet its physiological function is not known. Here, the authors report a role for Caspase-2 activity in synaptic plasticity via a reduction in dendritic spine density through cleavage of Rictor suggesting a mechanism to explain the impairments in cognitive flexibility observed in Caspase-2 knockout mice.
- Zhi-Xiang Xu
- , Ji-Wei Tan
- & Baoji Xu
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Article
| Open Access
Alcohol exposure disrupts mu opioid receptor-mediated long-term depression at insular cortex inputs to dorsolateral striatum
µ-opioid receptors (MOR) are known to modulate the reward effects of drugs of abuse, and MOR activation induces long-term depression (LTD) at striatal synapses. Here the authors show that alcohol exposure disrupts MOR-induced LTD only at specific cortical inputs to the striatum.
- Braulio Muñoz
- , Brandon M. Fritz
- & Brady K. Atwood
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Article
| Open Access
Cortical Up states induce the selective weakening of subthreshold synaptic inputs
Slow oscillations between cortical Up and Down states are a defining feature of deep sleep, but their function is not well understood. Here the authors study Up/Down states in acute slices of entorhinal cortex, and find that Up states promote the weakening of subthreshold synaptic inputs, while suprathreshold inputs are preserved or strengthened.
- Julian Bartram
- , Martin C. Kahn
- & Edward O. Mann
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Article
| Open Access
Timely regulated sorting from early to late endosomes is required to maintain cerebellar long-term depression
Long term depression (LTD) of the cerebellum is known to be mediated by postsynaptic trafficking of glutamate receptor AMPAR. Here, Kim and colleagues show that early- to late-endosomal sorting of AMPAR represents the switch from expression to maintenance phase of cerebellar LTD.
- Taegon Kim
- , Yukio Yamamoto
- & Keiko Tanaka-Yamamoto
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Article
| Open Access
ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion
The acid-sensing ion channel, ASIC1a, is known to play a role in synaptic transmission and plasticity. Here, the authors demonstrate a role for ASIC1a in regulating plasticity in the insular cortex and find that extinction of conditioned taste aversion memory is disrupted in the ASIC1a knockout mice.
- Wei-Guang Li
- , Ming-Gang Liu
- & Tian-Le Xu
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Article
| Open Access
Transduction of group I mGluR-mediated synaptic plasticity by β-arrestin2 signalling
mGluRs are known to undergo non-canonical signalling regulation, although the underlying mechanisms are unclear. Here, the authors identify a role for β-arrestin2, but not β-arrestin1, in group I mGluR-mediated plasticity at hippocampal synapses.
- Andrew G. Eng
- , Daniel A. Kelver
- & Geoffrey T. Swanson
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Article
| Open Access
mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo
In Alzheimer's disease, the soluble amyloid beta peptide is known to modulate synaptic function by forming a complex with prion proteins and metabotropic glutamate receptors. Here, Hu et al.show that amyloid beta signalling via this complex facilitates the induction of long-term depression at synapses.
- Neng-Wei Hu
- , Andrew J. Nicoll
- & Michael J. Rowan
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miR-191 and miR-135 are required for long-lasting spine remodelling associated with synaptic long-term depression
microRNAs inhibit mRNA translation and are implicated in modulating synaptic plasticity. Here, Hu et al.show that miR-191 and miR-135 regulate the expression of tropomodulin 2 and complexin-1/2 to produce dendritic spine remodelling, which is associated with synaptic long-term depression.
- Zhonghua Hu
- , Danni Yu
- & Zheng Li
Norepinephrine potentiates and serotonin depresses visual cortical responses by transforming eligibility traces