Featured
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Letter |
Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids
Calcium–lipid electrostatic interactions are shown to amplify the tyrosine phosphorylation of CD3ε and CD3ζ in T-cell antigen receptor complex.
- Xiaoshan Shi
- , Yunchen Bi
- & Chenqi Xu
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Letter |
Structure of the chemokine receptor CXCR1 in phospholipid bilayers
NMR spectroscopy is used to determine the three-dimensional structure of the full-length human chemokine receptor CXCR1 in phospholipid bilayers under physiological conditions.
- Sang Ho Park
- , Bibhuti B. Das
- & Stanley J. Opella
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News & Views |
Fat, bile and gut microbes
Western-style diets could be contributing to the rapid increase in inflammatory bowel disease. New research suggests that dietary fat can alter bile composition and so favour the growth of pro-inflammatory gut microbes. See Letter p.104
- Peter J. Turnbaugh
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Letter |
A PPARγ–FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis
PPARγ induces fibroblast growth factor 1 to remodel visceral adipose tissue in response to a high-fat diet to maintain metabolic homeostasis.
- Johan W. Jonker
- , Jae Myoung Suh
- & Ronald M. Evans
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News |
Clues to the cause of male pattern baldness
Lipid compound that suppresses hair growth in mice and men suggests treatment target.
- Melissa Lee Phillips
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Letter |
Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain
A sphingomyelin-binding motif is identified in the membrane-spanning domain of p24, a COPI machinery protein.
- F.-Xabier Contreras
- , Andreas M. Ernst
- & Britta Brügger
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Letter |
Dynamics of human adipose lipid turnover in health and metabolic disease
- Peter Arner
- , Samuel Bernard
- & Kirsty L. Spalding
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News |
Cholesterol crawls
A study tracking cholesterol movement within membranes suggests that it travels more slowly than expected.
- Nic Fleming
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Research Highlights |
Vesicles form with pH shift
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Research Highlights |
Omega-3s affect brain signalling
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Letter |
Calcium-dependent phospholipid scrambling by TMEM16F
Lipid asymmetry can be disrupted during biological processes such as apoptosis, during which phosphatidylserine in the inner leaflet of the membrane is exposed on the outer membrane. It has been proposed that activation of a phospholipid scramblase catalyses bidirectional transbilayer movement of phospholipids, but the protein corresponding to this activity has not been identified. Here, the protein TMEM16F is identified, and is an essential component for the Ca2+-dependent exposure of phosphatidylserine on the plasma membrane. A patient with Scott syndrome, which results from a defect in phospholipid scrambling activity, was found to carry a mutation in the gene encoding TMEM16F.
- Jun Suzuki
- , Masato Umeda
- & Shigekazu Nagata
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News |
Good news for 'good' cholesterol
Positive results inject life into strategy to treat heart disease.
- Alla Katsnelson
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Research Highlights |
Cell biology: Lung lipid hurts breathing
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Research Highlights |
Physiology: Fatty-acid effects
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News & Views |
Variations in blood lipids
What is the new gold standard for genome-wide association studies? As exemplified by analyses of blood lipids, it is collaboration to amass huge sample sizes and functional studies of the genes identified.
- Alan R. Shuldiner
- & Toni I. Pollin
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Research Highlights |
Cell biology: Live-action lipids
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Letter |
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
Engagement of the tumour-necrosis factor (TNF) receptor results in the assembly of multi-component signalling complexes by adaptor proteins that include TNF receptor-associated factor 2 (TRAF2). Genetic evidence indicates that TRAF2 is needed for the polyubiquitination of receptor interacting protein 1 (RIP1), but direct evidence has been lacking. Here it is shown that the lipid sphingosine-1-phosphate is a co-factor needed for this ubiquitination activity of TRAF2.
- Sergio E. Alvarez
- , Kuzhuvelil B. Harikumar
- & Sarah Spiegel
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Letter |
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
During atherosclerosis, crystals of cholesterol accumulate in atherosclerotic plaques. But are they a consequence or a cause of the inflammation associated with the disease? Here it is shown that small cholesterol crystals appear early in the development of atherosclerosis, and that they act as an endogenous danger signal, causing inflammation by activating the NLRP3 inflammasome pathway. Cholesterol crystals thus seem to be an early cause, rather than a late consequence, of inflammation.
- Peter Duewell
- , Hajime Kono
- & Eicke Latz
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Research Highlights |
Addiction: Junk-food junkies
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Letter |
Vascular endothelial growth factor B controls endothelial fatty acid uptake
VEGF–B is shown to have an unexpected role in targeting lipids to peripheral tissues. VEGF–B controls endothelial uptake of fatty acids via transcriptional regulation of vascular fatty acid transport proteins. Bioinformatic analyses suggest that the uptake of these lipids is tightly coupled with lipid use by mitochondria. Mice that do not have VEGF–B accumulate less lipids in muscle, heart and brown adipose tissue, and instead shunt them to white adipose tissue.
- Carolina E. Hagberg
- , Annelie Falkevall
- & Ulf Eriksson
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Article |
Orm family proteins mediate sphingolipid homeostasis
Mutations near the ORMDL3 gene have been associated with childhood asthma. Here, in yeast, Orm proteins are shown to function in sphingolipid homeostasis; alterations in this control result in misregulation of sphingolipid production and accumulation of toxic metabolites. This raises the testable hypothesis that misregulation of sphingolipids may directly contribute to the development of asthma.
- David K. Breslow
- , Sean R. Collins
- & Jonathan S. Weissman
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Brief Communications Arising |
Brinster et al. reply
- Sophie Brinster
- , Gilles Lamberet
- & Claire Poyart