Leukopoiesis articles within Nature Communications

Featured

• Article
  28 November 2022 | Open Access

  PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment

  Here the authors show that a Polycomb Repressive Complex 1 (PRC1) containing PCGF1 prevents excessive loading of transcriptional activators and chromatin remodelers on nascent DNA, allowing proper deposition of nucleosomes immediately after the passage of the DNA replication fork to optimize downstream chromatin configurations in hematopoietic stem and progenitor cells (HSPCs).

  • Junichiro Takano
  • , Shinsuke Ito
  •  & Tomokatsu Ikawa

• Article
  08 August 2022 | Open Access

  Competition between hematopoietic stem and progenitor cells controls hematopoietic stem cell compartment size

  Hematopoietic stem cells (HSCs) rely on a combination of paracrine signals produced by their niche, including SCF. Here the authors show that HSCs and hematopoietic progenitors compete for limited amounts of membrane-bound SCF.

  • Runfeng Miao
  • , Harim Chun
  •  & João P. Pereira

• Article
  25 November 2021 | Open Access

  Single-cell analysis identifies dynamic gene expression networks that govern B cell development and transformation

  The characterisation of B cell progenitors could benefit from single cell RNA analysis. Here the authors show distinct transcriptional profiles of B cell progenitors which are dependent upon pre-BCR and these profiles can be related to B cell transformation in lymphoblastic leukaemia.

  • Robin D. Lee
  • , Sarah A. Munro
  •  & Michael A. Farrar

• Article
  27 March 2018 | Open Access

  Ikaros family zinc finger 1 regulates dendritic cell development and function in humans

  IKZF1 is a transcription factor known to regulate mammalian B-cell development. Here the authors show that IKZF1 is required for human pDC development and regulation of DC cytokine production in patients with IKZF1 haploinsufficiency, findings which are recapitulated in lenalidomide-induced IKZF1 deficiency.

  • Urszula Cytlak
  • , Anastasia Resteu
  •  & Venetia Bigley

• Article
  08 January 2018 | Open Access

  Yolk sac macrophage progenitors traffic to the embryo during defined stages of development

  Tissue-resident macrophages are derived from yolk sac progenitors but how and when these progenitors enter is unclear. Here the authors use fate mapping and intravital microscopy to track the movement of resident macrophage precursors from the yolk sac to fetal tissues during development.

  • C. Stremmel
  • , R. Schuchert
  •  & C. Schulz

• Article | 19 September 2014

  IRF8 inhibits C/EBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils

  The mechanisms mediating lineage restriction in haematopoietic cell differentiation are not well understood. Here the authors show when and how the transcription factor IRF8 inhibits neutrophil differentiation during the lineage selection of monocytes and dendritic cells.

  • Daisuke Kurotaki
  • , Michio Yamamoto
  •  & Tomohiko Tamura