Featured
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Letter |
Optogenetic control of organelle transport and positioning
An optogenetic strategy allowing light-mediated recruitment of distinct cytoskeletal motor proteins to specific organelles is established; this technique enabled rapid and reversible activation or inhibition of the transport of organelles such as peroxisomes, recycling endosomes and mitochondria with high spatiotemporal accuracy, and the approach was also applied to primary neurons to demonstrate optical control of axonal growth by recycling endosome repositioning.
- Petra van Bergeijk
- , Max Adrian
- & Lukas C. Kapitein
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Letter |
Compartmentalized calcium dynamics in a C. elegans interneuron encode head movement
Subcellular compartmentalization established by mobilization of intracellular calcium stores in RIA interneurons provides a means of self-motion monitoring and a cellular basis for integrating sensory and motor signals in nematodes’ brains.
- Michael Hendricks
- , Heonick Ha
- & Yun Zhang