Inhibitory RNA techniques articles within Nature Communications

Featured

• Article
  16 August 2023 | Open Access

  Zwitterionic microgel preservation platform for circulating tumor cells in whole blood specimen

  Blood specimen stabilization for the preservation of circulating tumor cells remains challenging. Here, the authors present a zwitterionic microgel platform for long-term hypothermic preservation of circulating tumor cells in the whole blood of cancer patients for noninvasive diagnostics.

  • Yiming Ma
  • , Jun Zhang
  •  & Lei Zhang

• Article
  10 February 2021 | Open Access

  LETR1 is a lymphatic endothelial-specific lncRNA governing cell proliferation and migration through KLF4 and SEMA3C

  Long noncoding RNAs regulate tissue-specific gene expression. Here the authors profile lineage-specific lncRNAs in human dermal lymphatic and blood vascular endothelial cells (LECs and BECs) and show a role of LEC-specific lncRNA, LETR1, in cell proliferation and migration.

  • Luca Ducoli
  • , Saumya Agrawal
  •  & Michael Detmar

• Article
  09 April 2019 | Open Access

  Global identification of functional microRNA-mRNA interactions in Drosophila

  MicroRNAs are mediators of post-transcriptional gene expression silencing. Here authors provide a transcriptome-wide map of miRNA target sites in Drosophila.

  • Hans-Hermann Wessels
  • , Svetlana Lebedeva
  •  & Uwe Ohler

• Article
  03 January 2017 | Open Access

  Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells

  MicroRNAs regulate a wide range of biological processes and being able to inhibit their function could allow the development of therapeutic options. Here the authors describe a ‘small RNA zipper’ that sequesters miRNAs by forming a chain of DNA:RNA duplexes.

  • Lingyu Meng
  • , Cuicui Liu
  •  & Zuoren Yu