Inflammatory bowel disease articles within Nature

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  • Article
    | Open Access

    A new discovery strategy, ‘reverse metabolomics’, facilitates high-throughput matching of mass spectrometry spectra in public untargeted metabolomics datasets, and a proof-of-concept experiment identified an association between microbial bile amidates and inflammatory bowel disease.

    • Emily C. Gentry
    • , Stephanie L. Collins
    •  & Pieter C. Dorrestein

  • Article |

    A computational system termed MetaWIBELE (workflow to identify novel bioactive elements in the microbiome) is used to identify microbial gene products that are potentially bioactive and have a functional role in the pathogenesis of inflammatory bowel disease.

    • Yancong Zhang
    • , Amrisha Bhosle
    •  & Eric A. Franzosa

  • Article
    | Open Access

    Cells from embryonic, fetal, paediatric and adult human intestinal tissue are analysed at different locations along the intestinal tract to construct a single-cell atlas of the developing and adult human intestinal tract, encompassing all cell lineages.

    • Rasa Elmentaite
    • , Natsuhiko Kumasaka
    •  & Sarah A. Teichmann

  • Article |

    Mapping enhancer regulation across human cell types and tissues illuminates genome function and provides a resource to connect risk variants for common diseases to their molecular and cellular functions.

    • Joseph Nasser
    • , Drew T. Bergman
    •  & Jesse M. Engreitz

  • Article |

    In patients with ulcerative colitis, chronic inflammation can lead to remodelling of the colorectal epithelium through positive selection of clones with mutations in genes related to IL-17 signalling, which, however, might be negatively selected during colitis-associated carcinogenesis.

    • Nobuyuki Kakiuchi
    • , Kenichi Yoshida
    •  & Seishi Ogawa

  • Article
    | Open Access

    The Inflammatory Bowel Disease Multi’omics Database includes longitudinal data encompassing a multitude of analyses of stool, blood and biopsies of more than 100 individuals, and provides a comprehensive description of host and microbial activities in inflammatory bowel diseases.

    • Jason Lloyd-Price
    • , Cesar Arze
    •  & Curtis Huttenhower

  • Perspective
    | Open Access

    Over ten years, the Human Microbiome Project has provided resources for studying the microbiome and its relationship to disease; this Perspective summarizes the key achievements and findings of the project and its relationship to the broader field.

    • Lita M. Proctor
    • , Heather H. Creasy
    •  & Curtis Huttenhower

  • Article |

    Profiling of single epithelial cells in healthy and inflamed colons identifies specialized cellular subpopulations, including a type of goblet cell that secretes the antibacterial protein WFDC2, which preserves the integrity of the epithelial barrier layer.

    • Kaushal Parikh
    • , Agne Antanaviciute
    •  & Alison Simmons

  • Letter |

    Triangulation of microbe–phenotype relationships is an effective method for reducing the noise inherent in microbiota studies and enabling identification of causal microbes of disease, which may be applicable to human microbiome studies.

    • Neeraj K. Surana
    •  & Dennis L. Kasper

  • Outlook |

    Helminths are worms that can live in the human intestine. Joel Weinstock, a gastroenterologist at Tufts Medical Center in Boston, Massachusetts, studies how they affect inflammation and the body's immune response. He spoke to Nature about how helminths might lead to treatments for inflammatory bowel disease (IBD).

    • Neil Savage

  • Outlook |

    Gene exploration is providing unexpected insights into inflammatory bowel disease, and getting scientists closer to finding treatments that target the biological mechanisms.

    • Sarah DeWeerdt

  • Outlook |

    Four regenerative and immune-system therapies taking on the toughest cases of inflammatory bowel disease.

    • Eric Bender

  • Outlook |

    Transplants of faecal matter have done wonders for the treatment of certain gastrointestinal infections. Will they ever work for inflammatory bowel disease?

    • Liam Drew

  • Letter |

    Consuming diets rich in plant versus animal products changes the microbes found in the human gut within days, with important implications for our health and evolution.

    • Lawrence A. David
    • , Corinne F. Maurice
    •  & Peter J. Turnbaugh

  • Letter |

    Variation in ATG16L1, a protein involved in autophagy, confers risk for Crohn’s disease, but mice with hypomorphic ATG16L1 activity do not develop spontaneous intestinal inflammation; this study shows that autophagy compensates for endoplasmic reticulum stress — common in inflammatory bowel disease epithelium — specifically in Paneth cells, with Crohn’s-disease-like inflammation of the ileum originating from this cell type when both pathways are compromised.

    • Timon E. Adolph
    • , Michal F. Tomczak
    •  & Richard S. Blumberg

  • Letter |

    A meta-analysis of previous genome-wide association studies of Crohn’s disease and ulcerative colitis, the two most common forms of inflammatory bowel disease, with a combined total of more than 75,000 cases and controls, finds that most loci contribute to both phenotypes and other immune-mediated disorders.

    • Luke Jostins
    • , Stephan Ripke
    •  & Judy H Cho

  • News & Views |

    Western-style diets could be contributing to the rapid increase in inflammatory bowel disease. New research suggests that dietary fat can alter bile composition and so favour the growth of pro-inflammatory gut microbes. See Letter p.104

    • Peter J. Turnbaugh

  • News & Views |

    There are various ways in which apparently 'silent' DNA mutations — those that don't result in a change in the encoded protein — have untoward consequences. A striking example has emerged in a study of Crohn's disease.

    • Laurence D. Hurst

  • News & Views |

    Variations in several genes can increase an individual's susceptibility to complex disorders. But what tips the balance to cause the full-blown disease? For Crohn's disease, viruses could provide part of the answer.

    • Alison Simmons

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