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| Open AccessLipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses
The Lpp lipoproteins of staphylococci trigger a TLR2-dependent immune response. Here, the authors show that commensal species (S. aureus, S. epidermidis) induce a less-intense TLR2 response than non-commensal species (S. carnosus) due to differential modification of the Lpp lipid moieties.
- Minh-Thu Nguyen
- , Julia Uebele
- & Friedrich Götz
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Article
| Open AccessA structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells
Heligmosomoides polygyrus can activate mammalian TGF-β signalling pathways, but how it does so is not known. Here the authors identify and isolate a H. polygyrus TFG-β mimic that can bind both mammalian TGF-β receptor subunits, activate Smad signalling and generate inducible regulatory T cells.
- Chris J. C. Johnston
- , Danielle J. Smyth
- & Rick M. Maizels
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Article
| Open AccessGalectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration
Most tumours are poorly infiltrated by T cells. Here the authors show that galectin-3 secreted by tumours binds both glycosylated IFNγ and glycoproteins of the tumour extracellular matrix, thus avoiding IFNγ diffusion and the formation of an IFNγ-induced chemokine gradient required for T cell infiltration.
- Monica Gordon-Alonso
- , Thibault Hirsch
- & Pierre van der Bruggen
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Article
| Open AccessTumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis
Group 2 innate lymphoid cells (ILC2s) modulate inflammatory and allergic responses, but their function in cancer immunity is still unclear. Here the authors show that, in acute promyelocytic leukaemia, tumour-activated ILC2s secrete IL-13 to induce myeloid-derived suppressor cells and support tumour growth.
- Sara Trabanelli
- , Mathieu F. Chevalier
- & Camilla Jandus
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Article
| Open AccessNucleolin directly mediates Epstein-Barr virus immune evasion through binding to G-quadruplexes of EBNA1 mRNA
Cells infected with Epstein-Barr virus (EBV) express the virus-encoded EBNA1, which is essential for viral genome maintenance but also highly antigenic. Here the authors implicate nucleolin as a host factor that mediates the repression of EBNA1-derived antigenic peptides through binding of the G4-quadruplex structure present within the EBNA1 mRNA.
- María José Lista
- , Rodrigo Prado Martins
- & Marc Blondel
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Article
| Open AccessExpression of CD226 is associated to but not required for NK cell education
CD226 is an activating receptor expressed in a co-varied manner with inhibitory receptors on natural killer (NK) cells, but whether CD226 is involved in NK cell education is unclear. Here the authors show that CD226 expression is plastic depending on the MHC environment and endows educated NK cells enhanced effector functions.
- Arnika K. Wagner
- , Nadir Kadri
- & Benedict J. Chambers