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| Open AccessHTLV-1-induced leukotriene B4 secretion by T cells promotes T cell recruitment and virus propagation
HTLV-1 predominantly spreads through direct cell-cell contacts, but mechanisms of target cell recruitment are unclear. Here, the authors show that HTLV-1 infected T-cells secrete leukotriene B4, which recruits T-cells, facilitates HTLV-1 transmissionin vitro, and increases the number of infected clones in mice.
- Florent Percher
- , Céline Curis
- & Philippe V. Afonso