Homeostasis articles within Nature

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  • Article |

    Fasting-activated hypothalamic AgRP-expressing neurons trigger fasting-induced hypothalamic–pituitary–adrenal axis activation through projections to the paraventricular hypothalamus, where they activate CRH neurons by presynaptically inhibiting the terminals of tonically active GABAergic afferents from the bed nucleus of the stria terminalis.

    • Amelia M. Douglass
    • , Jon M. Resch
    •  & Bradford B. Lowell

  • Article |

    Detailed reconstruction using enhanced focused ion beam scanning electron microscopy imaging and deep-learning-based automated segmentation demonstrates that hepatocyte subcellular organelle architecture regulates metabolism.

    • Güneş Parlakgül
    • , Ana Paula Arruda
    •  & Gökhan S. Hotamışlıgil

  • Article |

    A specific neuronal population in the medial and lateral preoptic area of the hypothalamus regulates entry into torpor in mice.

    • Sinisa Hrvatin
    • , Senmiao Sun
    •  & Michael E. Greenberg

  • Letter |

    Drinking behaviour in mice is regulated by a signal derived from the water and salt content of the gastrointestinal tract that is transmitted to forebrain neurons that control thirst via the vagus nerve.

    • Christopher A. Zimmerman
    • , Erica L. Huey
    •  & Zachary A. Knight

  • Letter |

    SZT2 recruits GATOR1 and GATOR2 to form a SZT2-orchestrated GATOR (SOG) complex at the lysosome that is essential for GATOR- and SESN-dependent nutrient sensing and mTORC1 regulation.

    • Min Peng
    • , Na Yin
    •  & Ming O. Li

  • Letter |

    Group 2 innate lymphoid cells are shown to have a critical role in energy homeostasis by producing methionine-enkephalin peptides in response to interleukin 33, thus promoting the beiging of white adipose tissue; increased numbers of beige (also known as brown-like or brite) fat cells in white adipose tissue leads to increased energy expenditure and decreased adiposity.

    • Jonathan R. Brestoff
    • , Brian S. Kim
    •  & David Artis

  • Letter |

    The FXR–CREB axis is identified as a key physiological switch that regulates autophagy during feeding/fasting cycles; in the fed state, the nuclear receptor FXR is shown to suppress autophagy in the liver by inhibiting autophagy-associated lipid breakdown triggered under fasting conditions by the transcriptional activator CREB.

    • Sunmi Seok
    • , Ting Fu
    •  & Jongsook Kim Kemper

  • Letter |

    The nuclear receptors FXR and PPARα are shown to regulate autophagy by competing for binding to shared sites in the promoters of autophagic genes; in the fed state FXR suppresses hepatic autophagy, whereas in the fasted state PPARα is activated and reverses the normal suppression of autophagy.

    • Jae Man Lee
    • , Martin Wagner
    •  & David D. Moore

  • Letter |

    The identification of PILS proteins, putative auxin transport facilitators, suggests that intracellular auxin transport might be evolutionarily older than directional, cell-to-cell PIN-dependent auxin transport, and highlights the developmental importance of intracellular auxin transport.

    • Elke Barbez
    • , Martin Kubeš
    •  & Jürgen Kleine-Vehn

  • Article |

    The circadian clock fine-tunes the activation state of epidermal stem cells by regulating their ability to respond to their microenvironment; perturbation of this clock affects long-term tissue homeostasis and predisposition to tumorigenesis.

    • Peggy Janich
    • , Gloria Pascual
    •  & Salvador Aznar Benitah

  • News & Views |

    Humans must maintain a balanced composition for the trillions of commensal microbes that inhabit their gut, but how they do this is largely unclear. It now emerges that one factor is a molecular pathway in gut epithelial cells.

    • Menno van Lookeren Campagne
    •  & Vishva M. Dixit

  • News & Views |

    Blood cells are generated from haematopoietic stem cells on demand. The protein Lkb1, which lies at the crossroad of energy metabolism and cell growth, seems to regulate these stem cells' dynamics. See Articles p.653, p.659 & Letter p.701

    • Ellen M. Durand
    •  & Leonard I. Zon

  • Letter |

    Haematopoietic stem cells (HSCs) are very sensitive to energetic and oxidative stress, and modulation of the balance between their quiescence and proliferation is needed to respond to metabolic stress while preserving HSCs' long-term regenerative capacity. Here, and in two accompanying studies, it is shown that the tumour suppressor Lkb1 has a crucial role in maintaining energy homeostasis in haematopoietic cells.

    • Boyi Gan
    • , Jian Hu
    •  & Ronald A. DePinho

  • Article |

    Mutations near the ORMDL3 gene have been associated with childhood asthma. Here, in yeast, Orm proteins are shown to function in sphingolipid homeostasis; alterations in this control result in misregulation of sphingolipid production and accumulation of toxic metabolites. This raises the testable hypothesis that misregulation of sphingolipids may directly contribute to the development of asthma.

    • David K. Breslow
    • , Sean R. Collins
    •  & Jonathan S. Weissman

  • News & Views |

    Although sphingolipids are vital cellular components, the path to their production is paved with toxic intermediates. Orm proteins allow cells to form these lipids without killing themselves in the process.

    • Fikadu G. Tafesse
    •  & Joost C. M. Holthuis

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