Featured
-
-
Article
| Open AccessDeconvoluting hepatic processing of carbon nanotubes
Application of carbon nanotubes as drug delivery carriers is stalled by uncertainties over their distribution and toxicity in vivo. Here, the authors use animal models to show that, while the bulk of nanotubes is renally cleared, a fraction can be eliminated through an alternative hepatobiliary pathway.
- Simone Alidori
- , Robert L. Bowman
- & Michael R. McDevitt
-
Article
| Open AccessLATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development
The Hippo pathway regulates the differentiation of stem and progenitor cells, but it is unclear how it acts in liver development. Here, the authors knockout Hippo pathway components Lats1 and 2in the liver, causing suppression of hepatocyte differentiation but promoting biliary cell differentiation.
- Da-Hye Lee
- , Jae Oh Park
- & Dae-Sik Lim
-
Article
| Open AccessMicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression
Liver fibrosis is a pathogenic driver of many liver diseases, so understanding its regulation might open the door to new therapies. Here the authors perform a screen for miRNA candidates and identify that miR-378 inhibits liver fibrosis in mice by interfering with Hedgehog signalling in hepatic stellate cells.
- Jeongeun Hyun
- , Sihyung Wang
- & Youngmi Jung
-
Article
| Open AccessMICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration
Mitochondrial calcium uptake is a highly regulated process, and calcium overload can lead to cell death. Here, using knockout mouse model, the authors show that the mitochondrial calcium uniporter (MCU) regulator MICU1 is needed to prevent calcium overload and promotes survival under liver regeneration and postnatal adaptation-associated stress.
- Anil Noronha Antony
- , Melanie Paillard
- & György Hajnóczky
-
Article
| Open AccessHepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling
TRAF family proteins regulate immune signalling cascades. Here, the authors show that TRAF3 is upregulated in the liver in non-alcoholic fatty liver disease, promoting insulin resistance, inflammation and hepatic steatosis via its interaction with the kinase TAK1.
- Pi-Xiao Wang
- , Xiao-Jing Zhang
- & Hongliang Li
-
Article
| Open AccessBone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells
Tissue-resident macrophages are mostly derived from embryonic progenitors. Scott et al. develop a mouse model to specifically deplete Kupffer cells (KC) in vivoand show that monocyte-derived cells can repopulate KC niche and behave similar to their embryonically-derived counterparts.
- Charlotte L. Scott
- , Fang Zheng
- & Martin Guilliams
-
Article
| Open AccessGenetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6
There has been limited success in generating tissues from human induced pluripotent stem cells (hiPSCs). Here, the authors genetically engineer expression of the transcription factor Gata6 in a single isogenic hiPSC population resulting in complex tissue structures that exhibit liver bud-like properties.
- Patrick Guye
- , Mohammad R. Ebrahimkhani
- & Ron Weiss
-
Article
| Open AccessESRP2 controls an adult splicing programme in hepatocytes to support postnatal liver maturation
Alternative RNA splicing is important during organismal development. Here, the authors perform RNA-Seq on mouse and human liver samples to provide a comprehensive view of splicing events during liver development and growth, and identify Espr2 as a main regulator of these splicing processes.
- Amruta Bhate
- , Darren J. Parker
- & Auinash Kalsotra
-
Article |
Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver
NADPH acts as a reducing currency in mammalian cells and is thought to be required to maintain redox homeostasis. Here the authors discover an alternative NADPH-independent pathway, based on the conversion of methionine into cysteine, which is capable of sustaining redox homeostasis in the mouse liver.
- Sofi Eriksson
- , Justin R. Prigge
- & Edward E. Schmidt
-
Article |
Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors
The transcription factors FoxoO1 and Srebp-1 control hepatic glucose and lipid production, respectively. Here, Haeusler et al.propose a model that integrates glucose and lipid regulation in the normal and diabetic liver under the unifying control of FoxO transcription factors.
- Rebecca A. Haeusler
- , Kirsten Hartil
- & Domenico Accili