GTP-binding protein regulators articles within Nature

Featured

• Article | 13 March 2024

  Time-resolved cryo-EM of G-protein activation by a GPCR

  Time-resolved cryo-EM is used to capture structural transitions during G-protein activation stimulated by a G-protein-coupled receptor.

  • Makaía M. Papasergi-Scott
  • , Guillermo Pérez-Hernández
  •  & Georgios Skiniotis

• Article | 13 October 2021

  Systems-level effects of allosteric perturbations to a model molecular switch

  Interface mutations in the GTPase switch protein Gsp1 (the yeast homologue of human RAN) allosterically affect the kinetics of the switch cycle, revealing a systems-level mechanism of multi-specificity.

  • Tina Perica
  • , Christopher J. P. Mathy
  •  & Tanja Kortemme

• Letter | 22 February 2016

  Crystal structure of eukaryotic translation initiation factor 2B

  The crystal structure of Schizosaccharomyces pombe guanine nucleotide exchange factor eIF2B, providing a structural framework for the eIF2B-mediated mechanism of stress-induced translational control.

  • Kazuhiro Kashiwagi
  • , Mari Takahashi
  •  & Shigeyuki Yokoyama