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| Open AccessSirt2 promotes white matter oligodendrogenesis during development and in models of neonatal hypoxia
Neonatal hypoxia leads to white matter hypomyelination due to delayed oligodendrocyte maturation. The authors identify Sirt2 as a crucial regulator of oligodendrocyte differentiation during normal white matter development and in response to hypoxia.
- Beata Jablonska
- , Katrina L. Adams
- & Vittorio Gallo
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Article
| Open AccessImpaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior
Early postnatal interruption of the bidirectional GABA/TNFSF12 signaling between parvalbumin-positive interneurons and oligodendrocyte precursor cells impairs correct prefrontal cortical network activity and social cognitive behavior later in life.
- Li-Pao Fang
- , Na Zhao
- & Xianshu Bai
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Article
| Open AccessNeuronal processes and glial precursors form a scaffold for wiring the developing mouse cochlea
In developing embryos, axons grow through complex and dynamic terrains. Here, the authors show that spiral ganglion neurons in the developing mouse cochlea extend leading axons that interact with a scaffold of glial precursors, with follower axons fasciculating on top.
- N. R. Druckenbrod
- , E. B. Hale
- & L. V. Goodrich
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Article
| Open AccessCenpj/CPAP regulates progenitor divisions and neuronal migration in the cerebral cortex downstream of Ascl1
The proneural factor Ascl1/Mash1 is an important regulator of embryonic neurogenesis. Here the authors identify that the microcephaly protein Cenpj/CPAP is essential for several microtubule-dependent steps in the neurogenic program driven by Ascl1 in the developing cerebral cortex.
- Patricia P. Garcez
- , Javier Diaz-Alonso
- & François Guillemot
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Article
| Open AccesshESC-derived Olig2+ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury
Astroglia are heterogeneous in phenotype and not all astrocytes are equivalent in their ability to repair injured brain. Here, the authors show that two defined subtypes of astroglia generated from hESC-derived Olig2-positive versus Olig2-negative neural progenitors, exhibit distinct properties and neuroprotective effects.
- Peng Jiang
- , Chen Chen
- & Wenbin Deng