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Reynolds and colleagues examine a biochemically-mediated epistatic interaction between metabolic enzymes involved in folate metabolism and show that biochemical coupling shapes the range of enzyme activities sufficient to rescue cell growth.
In this Review, Mackay and Anholt discuss how epistasis and pleiotropy contribute to the genetic architecture of quantitative traits and outline factors that might explain observed differences in their prevalence between model organisms and humans.
A new study strengthens the association between urbanicity and mental health with more granularity than before, but a causative mechanism remains elusive.
Large-scale CRISPRi chemical genetic screening in Mycobacterium tuberculosis identifies genes altering antibiotic potency and the repurposing of the antibiotic clarithromycin to treat tuberculosis in Southeast Asia.
Genetic-interaction mapping and co-essentiality analyses in human cells reveal the orphan gene C12orf49 (also known as SPRING1) as a novel regulator of lipid-metabolism homeostasis.