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| Open AccessIntestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice
The mechanisms that mediate the effects of weight loss surgeries such as vertical sleeve gastrectomy (VSG) are incompletely understood. Here the authors show that intestinal FGF15 is necessary to improve glucose tolerance and to prevent the loss of muscle and bone mass after VSG, potentially via protection against bile acid toxicity.
- Nadejda Bozadjieva-Kramer
- , Jae Hoon Shin
- & Randy J. Seeley
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Article
| Open AccessBariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells
GLP-1 is a gastrointestinal peptide that regulates gastric acid secretion and emptying, and due to the rapid degradation of intestinally secreted GLP-1 local gastric production has been suggested. Here the authors report the presence of GLP-1 expressing cells in the rat and human stomach, which contribute to the circulating GLP-1 levels and are affected by weight loss surgeries.
- Lara Ribeiro-Parenti
- , Anne-Charlotte Jarry
- & André Bado
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Article
| Open AccessEnteroendocrine cells couple nutrient sensing to nutrient absorption by regulating ion transport
Enteroendocrine cells (EECs) are specialized gastrointestinal cells that have a role in nutrient sensing and hormone secretion. Here the authors show that peptide YY from EECs regulates nutrient absorption in intestinal organoids.
- Heather A. McCauley
- , Andrea L. Matthis
- & James M. Wells
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Article
| Open AccessRestriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution
Dietary protein dilution, where protein is reduced and replaced by other nutrient sources without caloric restriction, promotes metabolic health via the hepatokine Fgf21. Here, the authors show that essential amino acids threonine and tryptophan are necessary and sufficient to induce these effects.
- Yann W. Yap
- , Patricia M. Rusu
- & Adam J. Rose