Fungal pathogenesis articles within Nature

Featured

  • Article |

    This study identifies a cytolytic peptide toxin in the opportunistic human fungal pathogen Candida albicans—the peptide is both a crucial virulence factor that permeabilizes the host cell plasma membrane and a key signal that triggers a host danger response pathway.

    • David L. Moyes
    • , Duncan Wilson
    •  & Julian R. Naglik

  • Letter |

    Fungal pathogens reorient hyphal growth towards their plant hosts in response to chemical signals; here, directed growth of the plant pathogen Fusarium oxysporum towards the roots of the tomato plant is shown to be triggered by class III peroxidases secreted by the tomato plant, with the fungal response requiring a sex pheromone receptor.

    • David Turrà
    • , Mennat El Ghalid
    •  & Antonio Di Pietro

  • Letter |

    The human fungal pathogen Mucor circinelloides develops spontaneous resistance to an antifungal drug both through mutation and through a newly identified epigenetic RNA-mediated pathway; RNA interference is spontaneously triggered to silence the fkbA gene, giving rise to drug-resistant epimutants that revert to being drug-sensitive once again when grown in the absence of drug.

    • Silvia Calo
    • , Cecelia Shertz-Wall
    •  & Joseph Heitman

  • News & Views |

    An aggressive and unpredictable fungal pathogen is devastating larch plantations in Britain. Its remarkably broad host range, and the possibility of further geographical spread, give heightened cause for concern.

    • Clive Brasier
    •  & Joan Webber

  • Article
    | Open Access

    Fungi from the genus Fusarium are important pathogens of animals and crop plants. Some have a wide host range, whereas others are more specific in the organisms they infect. Here, clues are provided as to how differences in specificity come about. The genomes of two Fusarium fungi with differing host ranges have been sequenced, and compared with the genome of a third species. Experiments show that transferring two whole chromosomes turns a non-pathogenic Fusarium strain into a pathogenic one.

    • Li-Jun Ma
    • , H. Charlotte van der Does
    •  & Martijn Rep

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