ESCRT articles within Nature

Featured

• Letter | 03 June 2015

  Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

  ESCRT-III, a protein complex best known for membrane constriction and sealing during various cellular processes, mediates reassembly of the nuclear envelope during late anaphase.

  • Marina Vietri
  • , Kay O. Schink
  •  & Harald Stenmark

• Letter | 03 June 2015

  ESCRT-III controls nuclear envelope reformation

  The ESCRT-III complex is implicated in the reformation of the nuclear envelope; the CHMP2A component of ESCRT-III is directed to the forming nuclear envelope through classical ESCRT-assembly mechanisms, with the help of the p97 complex component UFD1, and provides an activity essential for nuclear envelope reformation.

  • Yolanda Olmos
  • , Lorna Hodgson
  •  & Jeremy G. Carlton

• Letter | 03 December 2014

  The ESCRT machinery regulates the secretion and long-range activity of Hedgehog

  A new role for the endosomal sorting complex required for transport (ESCRT) is identified in fly larvae, where it is shown to be essential for the secretion and long-range signalling of the embryonic development morphogen Hedgehog.

  • Tamás Matusek
  • , Franz Wendler
  •  & Pascal P. Thérond

• Article | 21 March 2010

  Molecular mechanism of multivesicular body biogenesis by ESCRT complexes

  Here, multivesicular body (MVB) biogenesis is reconstituted using giant unilamellar vesicles and all of the ESCRT complexes. ESCRT-0 is required for clustering of cargo proteins, whereas ESCRT-I and -II in combination deform the membrane into buds, in which cargo is confined. ESCRT-III subunits localize to the bud neck and are required for scission of the membrane to form intraluminal vesicles. These results explain how ESCRT complexes sequester cargo proteins into MVBs.

  • Thomas Wollert
  •  & James H. Hurley