DNA mismatch repair articles within Nature

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• Letter | 16 November 2016

  Cascading MutS and MutL sliding clamps control DNA diffusion to activate mismatch repair

  MutS and MutL—the highly conserved core proteins responsible for the repair of mismatched DNA—form sequential stable sliding clamps that together modulate one-dimensional diffusion along the DNA and, with MutH, facilitate the search for a distant excision initiation site.

  • Jiaquan Liu
  • , Jeungphill Hanne
  •  & Richard Fishel

• Letter | 23 February 2015

  Differential DNA mismatch repair underlies mutation rate variation across the human genome

  An analysis of how regional mutation rates vary across 652 tumours identifies variable DNA mismatch repair as the basis of the characteristic regional variation in mutation rates seen across the human genome; the results show that differential DNA repair, rather than differential mutation supply, is likely to be the primary cause of this variation.

  • Fran Supek
  •  & Ben Lehner