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Letter |
Polyglutamine tracts regulate beclin 1-dependent autophagy
The polyglutamine domain in ataxin 3, which is expanded in spinocerebellar ataxia type 3, allows normal ataxin 3 to interact with and deubiquitinate beclin 1 and thereby to promote autophagy.
- Avraham Ashkenazi
- , Carla F. Bento
- & David C. Rubinsztein
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Letter |
USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites
The proteasome-associated enzyme USP14 regulates protein degradation by removing ubiquitin from proteins; here it is shown that USP14 removes ubiquitin chains from in vitro generated cyclin B conjugates en bloc and within milliseconds, before the proteasome has a chance to initiate degradation, and proceeds until a single chain remains.
- Byung-Hoon Lee
- , Ying Lu
- & Daniel Finley
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Letter |
USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110
Maintenance of normal levels of CP110 is essential to prevent over-duplication of centrosomes and genome instability; here, a deubiquitinating enzyme, USP33, is shown to stabilize CP110.
- Ji Li
- , Vincenzo D’Angiolella
- & Brian David Dynlacht
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Letter |
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma
An in vivo transposon screen in a pancreatic cancer model identifies frequent inactivation of Usp9x; deletion of Usp9x cooperates with KrasG12D to accelerate rapidly pancreatic tumorigenesis in mice, validating their genetic interaction.
- Pedro A. Pérez-Mancera
- , Alistair G. Rust
- & David A. Tuveson
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Letter |
The mechanism of OTUB1-mediated inhibition of ubiquitination
OTUB1 is an atypical deubiquitinating enzyme which prevents ubiquitin attachment and is important in the DNA damage pathway; structural analysis of OTUB1 in complex with an E2 ubiquitin-conjugating enzyme reveals that the ability of OTUB1 to inhibit ubiquitin chain synthesis is regulated by an allosteric feedback mechanism.
- Reuven Wiener
- , Xiangbin Zhang
- & Cynthia Wolberger