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| Open AccessDesmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination
The epidermis is a multi-layered epithelium formed by the differentiation of basal cells and movement into suprabasal layers. Here the authors define a role for the desmosomal cadherin desmoglein-1 in promoting the delamination of basal cells by remodeling the actin cytoskeleton through interactions with the dynein light chain Tctex-1 and cortactin.
- Oxana Nekrasova
- , Robert M. Harmon
- & Kathleen J. Green
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Article |
A novel Nrf2-miR-29-desmocollin-2 axis regulates desmosome function in keratinocytes
Desmosomes are adhesive junctions that are essential for epithelial barrier function. Here, Kurinna et al. identify a role for the transcription factor Nrf2 in regulating the expression of micro-RNA genes that control the integrity of desmosomes, through modulating the expression of desmocollin-2.
- Svitlana Kurinna
- , Matthias Schäfer
- & Sabine Werner