Dengue virus articles within Nature Communications

Featured

• Article
  25 April 2024 | Open Access

  Travel surveillance uncovers dengue virus dynamics and introductions in the Caribbean

  Dengue is a major public health concern in the Americas, and the Caribbean can be a source for reintroduction and spread. Here, the authors use travel surveillance data and genomic epidemiology to reconstruct Dengue epidemic dynamics in the Caribbean from 2009-2022.

  • Emma Taylor-Salmon
  • , Verity Hill
  •  & Nathan D. Grubaugh

• Article
  27 March 2024 | Open Access

  Trade-offs shaping transmission of sylvatic dengue and Zika viruses in monkey hosts

  Hanley et al show that transmission of dengue and Zika virus from Old and New World monkeys is shaped by an immunologically-mediated trade-off between magnitude and duration of replication. Patterns of Zika transmission suggests high risk of spillback into neotropical monkeys.

  • Kathryn A. Hanley
  • , Hélène Cecilia
  •  & Shannan L. Rossi

• Article
  09 January 2024 | Open Access

  Protection against symptomatic dengue infection by neutralizing antibodies varies by infection history and infecting serotype

  There is still a need to improve understanding of dengue-specific immunity. Here, by analyzing the antibody response in a pediatric cohort the authors show that the protective capacity of neutralizing antibodies depends on infection history and serotype, but its estimation varies by assay condition and virion maturation.

  • Sandra Bos
  • , Aaron L. Graber
  •  & Eva Harris

• Article
  05 January 2024 | Open Access

  Nuclear membrane protein SUN2 promotes replication of flaviviruses through modulating cytoskeleton reorganization mediated by NS1

  Here, Huang et al. show that nuclear membrane proteins SUN2 and Nesprins are required for the in vitro and in vivo replication of Zika virus, through directing the cytoskeleton remodeling and formation of replication organelles mediated by viral NS1.

  • Yanxia Huang
  • , Qinyu Peng
  •  & Ping Zhang

• Article
  02 January 2024 | Open Access

  Multiplexed multicolor antiviral assay amenable for high-throughput research

  Antiviral approaches against entire genera or families of viruses need to be constantly developed and innovated. Focusing on several distantly-related orthoflaviviruses, the authors develop a cell-based multiplex antiviral assay for high-throughput screening against multiple viruses at once.

  • Li-Hsin Li
  • , Winston Chiu
  •  & Kai Dallmeier

• Article
  13 March 2023 | Open Access

  A live dengue virus vaccine carrying a chimeric envelope glycoprotein elicits dual DENV2-DENV4 serotype-specific immunity

  Here, the authors report a live chimeric DENV2/4 EDII virus, encoding DENV2 and DENV4 neutralizing epitopes, that replicates efficiently in primates and simultaneously elicits neutralizing DENV2 and DENV4 type-specific antibodies, providing domain-specific diagnostic reagents and simplified vaccine strategies.

  • Ellen Young
  • , Boyd Yount
  •  & Ralph S. Baric

• Article
  09 November 2022 | Open Access

  CryoEM structures of the multimeric secreted NS1, a major factor for dengue hemorrhagic fever

  The extracellular secreted NS1 (sNS1) is a major factor contributing to dengue hemorrhagic fever. Here, Shu et al. report sNS1 exists in multiple oligomeric states and presents a tetrameric structure.

  • Bo Shu
  • , Justin S. G. Ooi
  •  & Shee-Mei Lok

• Article
  22 February 2022 | Open Access

  Fine-scale heterogeneity in population density predicts wave dynamics in dengue epidemics

  Population density can influence the dynamics of emerging infections, but the specific effects at a local (within-city) level are not well understood. Here, the authors investigate the influence of population density on dynamics of dengue outbreaks in Rio de Janeiro and propose that this variable holds the key to how space should be aggregated.

  • Victoria Romeo-Aznar
  • , Laís Picinini Freitas
  •  & Mercedes Pascual

• Article
  16 December 2021 | Open Access

  Single dose of chimeric dengue-2/Zika vaccine candidate protects mice and non-human primates against Zika virus

  Here the authors generate a live-attenuated Zika vaccine based on a clinically proven dengue virus serotype-2 vaccine backbone and show that one dose protects mice and non-human primates from Zika virus infection.

  • Whitney R. Baldwin
  • , Holli A. Giebler
  •  & Claire Y.-H. Huang

• Article
  01 June 2021 | Open Access

  A unified route for flavivirus structures uncovers essential pocket factors conserved across pathogenic viruses

  Understanding virus assembly could identify potential drug targets. Here the authors use a safe and efficient method to solve pathogenic flavivirus structures, revealing two lipid-like ligands within highly conserved pockets of the stem region of envelope protein that are important for virus maturation.

  • Joshua M. Hardy
  • , Natalee D. Newton
  •  & Daniel Watterson

• Article
  11 May 2021 | Open Access

  Lying in wait: the resurgence of dengue virus after the Zika epidemic in Brazil

  Zika and dengue incidence in the Americas declined in 2017–2018, but dengue resurged in 2019 in Brazil. This study uses epidemiological, climatological and genomic data to show that the decline of dengue may be explained by protective immunity from pre-exposure to ZIKV and/or DENV in prior years.

  • Anderson Fernandes Brito
  • , Lais Ceschini Machado
  •  & Nathan D. Grubaugh

• Article
  05 May 2021 | Open Access

  Structures of flavivirus RNA promoters suggest two binding modes with NS5 polymerase

  Flaviviruses use a ~70 nucleotide stem-loop structure called stem-loop A (SLA) at the 5’ end of the RNA genome as a promoter for RNA synthesis by the viral polymerase NS5. Here the authors describe the structures of dengue and Zika virus SLAs, identify the SLA-binding site on NS5, and propose models for how NS5 recognizes the RNA promoter.

  • Eunhye Lee
  • , Paul J. Bujalowski
  •  & Kyung H. Choi

• Article
  16 April 2021 | Open Access

  Field and classroom initiatives for portable sequence-based monitoring of dengue virus in Brazil

  Here, the authors present results of the ZiBRA-2 project (https://www.zibra2project.org) which is an arbovirus surveillance project, across the Midwest of Brazil using a mobile genomics laboratory, combined with a genomic surveillance training program that targeted post-graduate students, laboratory technicians, and health practitioners in universities and laboratories.

  • Talita Émile Ribeiro Adelino
  • , Marta Giovanetti
  •  & Luiz Carlos Junior Alcantara

• Article
  22 March 2021 | Open Access

  Reconstructing unseen transmission events to infer dengue dynamics from viral sequences

  Phylogeographic analyses can provide broad descriptions of the spread of pathogens between populations, but are limited by incomplete sampling. Here, the authors develop an inference framework that reconstructs sequential transmission events and use it to characterise dynamics of dengue in Thailand.

  • Henrik Salje
  • , Amy Wesolowski
  •  & Derek A. T. Cummings

• Article
  15 March 2021 | Open Access

  Interactions between timing and transmissibility explain diverse flavivirus dynamics in Fiji

  Dengue and Zika virus are closely related flaviviruses but can have contrasting transmission dynamics in the same populations. Here, the authors use a model combining serological, surveillance and viral sequence data to explain differences in transmission dynamics in Fiji.

  • Alasdair D. Henderson
  • , Mike Kama
  •  & Adam J. Kucharski

• Article
  23 February 2021 | Open Access

  Flavivirus maturation leads to the formation of an occupied lipid pocket in the surface glycoproteins

  Here, the authors provide cryo-EM structures of mature and immature Spondweni virus, defining the furin recognition site at high resolution, and identifying a lipid that binds E upon capsid maturation and is also present in Zika and Dengue virions.

  • Max Renner
  • , Wanwisa Dejnirattisai
  •  & Jonathan M. Grimes

• Article
  17 February 2021 | Open Access

  A tetravalent live attenuated dengue virus vaccine stimulates balanced immunity to multiple serotypes in humans

  Multivalent vaccines that confer protection to multiple serotypes of Dengue virus have been established. Here the authors examine the presence of vaccine induced multivalent antibodies and how these link to protection in a human challenge model of Dengue virus.

  • Usha K. Nivarthi
  • , Jesica Swanstrom
  •  & Aravinda M. de Silva

• Article
  08 January 2021 | Open Access

  Asynchronicity of endemic and emerging mosquito-borne disease outbreaks in the Dominican Republic

  Dengue is endemic in the Dominican Republic, and causes regular outbreaks, whereas Zika and chikungunya are emerging infections in the area. Here, the authors show that outbreaks of the emerging infections could not be predicted by seasonal dengue dynamics.

  • Mary E. Petrone
  • , Rebecca Earnest
  •  & Leandro Tapia

• Article
  19 October 2020 | Open Access

  Antibodies targeting epitopes on the cell-surface form of NS1 protect against Zika virus infection during pregnancy

  Zika virus is an arthropod-transmitted flavivirus that can cause microcephaly and other fetal abnormalities during pregnancy. Here Wessel et al. develop antibodies against the Zika virus nonstructural protein 1 that protect non-pregnant and pregnant mice against infection, and define particular antibody epitopes and mechanisms underlying this protection.

  • Alex W. Wessel
  • , Nurgun Kose
  •  & Michael S. Diamond

• Article
  15 October 2020 | Open Access

  Lyn kinase regulates egress of flaviviruses in autophagosome-derived organelles

  Egress of flaviviruses and involved host pathways are not well understood. Here, the authors show that Lyn is a critical host kinase for Dengue and Zika virus egress resulting in infectious virus progenies within autophagosome-derived vesicles, which might help the virus to evade antibody responses.

  • Ming Yuan Li
  • , Trupti Shivaprasad Naik
  •  & Sumana Sanyal

• Article
  23 June 2020 | Open Access

  TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis

  The mechanisms underlying immunpathologies in dengue virus (DENV) infection are incompletely understood. Here, authors show that TLR2 recognizes DENV particles inducing cytokine expression and activating vascular endothelium cells in vitro, and that TLR2 expression on monocytes correlates with disease severity in patients.

  • José A. Aguilar-Briseño
  • , Vinit Upasani
  •  & Izabela A. Rodenhuis-Zybert

• Article
  19 June 2020 | Open Access

  High flavivirus structural plasticity demonstrated by a non-spherical morphological variant

  Dengue (DENV) and Zika (ZIKV) viruses normally display as smooth spherical particles, while DENV can also become bumpy-surfaced, resulting in immune evasion. Here, Morrone et al. report DENV and ZIKV infectious club-shaped particles (clubSP) that display distinct antibody binding properties.

  • Seamus R. Morrone
  • , Valerie S. Y. Chew
  •  & Shee-Mei Lok

• Article
  14 February 2020 | Open Access

  Capsid protein structure in Zika virus reveals the flavivirus assembly process

  The structure of flavivirus surface proteins has been elucidated, but the conformation of capsid proteins within particles is less clear. Here, the authors provide a subnanometer resolution structure of Zika virus capsid protein within the virus particle, elucidating its quaternary organization and role in flavivirus packaging.

  • Ter Yong Tan
  • , Guntur Fibriansah
  •  & Shee-Mei Lok

• Article
  16 December 2019 | Open Access

  Impacts of Zika emergence in Latin America on endemic dengue transmission

  Dengue and Zika virus are related flaviviruses, and introduction of Zika in the Americas may have impacted dengue epidemiology. Here, Borchering et al. show that dengue incidence was unusually low in 2017 in Brazil and Colombia, and simulations incorporating immune-mediated interactions predict reductions in dengue following Zika outbreaks with subsequent rebounds.

  • Rebecca K. Borchering
  • , Angkana T. Huang
  •  & Derek A. T. Cummings

• Article
  20 September 2019 | Open Access

  Time elapsed between Zika and dengue virus infections affects antibody and T cell responses

  Here, the authors show that the time elapsed between Zika infection and subsequent dengue virus infection affects the magnitude and durability of the antibody and cell-mediated immune responses against dengue virus, but not viremia. This research in non-human primates has implications for co-endemic regions and vaccination.

  • Erick X. Pérez-Guzmán
  • , Petraleigh Pantoja
  •  & Carlos A. Sariol

• Article
  14 August 2019 | Open Access

  Dissecting the heterogeneity of DENV vaccine-elicited cellular immunity using single-cell RNA sequencing and metabolic profiling

  Using a combination of single-cell RNA sequencing and TCR clonotype analysis on longitudinal samples from dengue vaccinated individuals, Waickman et al. here define a transcriptional signature in acutely-activated T cells that is associated with durable CD8⁺ T cell memory.

  • Adam T. Waickman
  • , Kaitlin Victor
  •  & Jeffrey R. Currier

• Article
  29 March 2019 | Open Access

  Structure mapping of dengue and Zika viruses reveals functional long-range interactions

  Here, the authors provide detailed analyses of viral RNA structure in virions and in infected cells for four dengue virus serotypes and four Zika virus strains, and identify conserved structures that are important for virus replication.

  • Roland G. Huber
  • , Xin Ni Lim
  •  & Yue Wan

• Article
  08 March 2019 | Open Access

  Inter-annual variation in seasonal dengue epidemics driven by multiple interacting factors in Guangzhou, China

  In 2014 Guangzhou, China experienced its worse dengue epidemic on record. To determine the reasons for this the authors model historical data under combinations of four time-varying factors and find that past epidemics were limited by one or more unfavourable conditions, but the 2014 epidemic faced none of these restraints.

  • Rachel J. Oidtman
  • , Shengjie Lai
  •  & Hongjie Yu

• Article
  26 February 2019 | Open Access

  Impact of pre-existing dengue immunity on human antibody and memory B cell responses to Zika

  Here, Andrade et al. assess the memory B cell (MBC) and antibody response to Zika virus (ZIKV) in individuals with and without prior dengue virus (DENV) infection and find that ZIKV infection elicits a robust and specific MBC response that is only modestly affected by the number of prior DENV infections.

  • Paulina Andrade
  • , Ciara Gimblet-Ochieng
  •  & Eva Harris

• Article
  22 January 2019 | Open Access

  The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication

  The circadian clock can affect pathogen replication, but underlying molecular mechanisms are unclear. Here the authors demonstrate that the circadian components BMAL1 and REV-ERBα affect entry of hepatitis C virus (HCV) into hepatocytes and genome replication of HCV and related flaviviruses dengue and zika.

  • Xiaodong Zhuang
  • , Andrea Magri
  •  & Jane A. McKeating

• Article
  07 September 2018 | Open Access

  Refined efficacy estimates of the Sanofi Pasteur dengue vaccine CYD-TDV using machine learning

  Clinical trials for the CYD-TDV dengue vaccine showed that vaccine efficacy varies with prior dengue exposure, but baseline serostatus is only known for 12% of subjects. Here, Dorigatti et al. use machine learning to impute baseline serostatus and determine vaccine efficacy by baseline serostatus, age and dengue serotype.

  • I. Dorigatti
  • , C. A. Donnelly
  •  & N. M. Ferguson

• Article
  13 November 2017 | Open Access

  Dengue virus-reactive CD8⁺ T cells mediate cross-protection against subsequent Zika virus challenge

  Dengue virus-specific antibody and CD8⁺ T cells that cross-react with Zika virus have been described. Here, the authors establish a functionally protective role for cross-reactive dengue virus-specific CD8⁺ T cells during challenge with Zika virus.

  • Jinsheng Wen
  • , Annie Elong Ngono
  •  & Sujan Shresta

• Article
  02 November 2017 | Open Access

  Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system

  Transmission of many human viruses depends on replication in their mosquito vectors. Here, Zhu et al. show that glutamic acid digested from the blood meal activates GABA signaling, resulting in suppression of antiviral innate immunity and increased virus replication in mosquitoes.

  • Yibin Zhu
  • , Rudian Zhang
  •  & Gong Cheng

• Article
  13 September 2017 | Open Access

  Perturbed cholesterol and vesicular trafficking associated with dengue blocking in Wolbachia-infected Aedes aegypti cells

  Wolbachia infection of mosquitoes can block dengue virus infection and is tested in field trials, but the mechanism of action is unclear. Using proteomics, Geoghegan et al. here identify effects of Wolbachia on cholesterol homeostasis and dengue virus replication in Aedes aegypti.

  • Vincent Geoghegan
  • , Kirsty Stainton
  •  & Steven P. Sinkins

• Article
  23 June 2017 | Open Access

  Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus

  Antibodies against dengue virus (DENV) can increase Zika virus (ZIKV) infectionin vitro, but their role in vivoremains largely unknown. Here, the authors show that pre-existing immunity from a 2.8 years earlier DENV infection does not affect ZIKV pathogenesis in macaques but instead shortens Zika viremia.

  • Petraleigh Pantoja
  • , Erick X. Pérez-Guzmán
  •  & Carlos A. Sariol

• Article
  23 May 2017 | Open Access

  Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope

  The immunodominant epitope of dengue virus envelope protein (E) induces poorly neutralizing antibodies, which poses a problem for vaccine development. Here, the authors engineer covalently locked E dimers exposing an epitope that has been shown to induce potent and broadly neutralizing antibodies.

  • Alexander Rouvinski
  • , Wanwisa Dejnirattisai
  •  & Gavin R. Screaton

• Article
  19 May 2017 | Open Access

  Impact of simultaneous exposure to arboviruses on infection and transmission by Aedes aegypti mosquitoes

  Several mosquito-transmitted viruses cocirculate in the Americas, but the potential for co-transmission is unknown. Here, Rückertet al. show that Aedes aegyptimosquitos have the potential to co-transmit chikungunya, dengue and Zika viruses and that coinfection does not overall affect dissemination or transmission rates.

  • Claudia Rückert
  • , James Weger-Lucarelli
  •  & Gregory D. Ebel

• Article
  10 February 2017 | Open Access

  Conformational changes in intact dengue virus reveal serotype-specific expansion

  Temperature differences between mosquitoes and humans trigger structural changes in dengue virus 2 (DENV2) particles, but not in other DENV serotypes. Here, using HDXMS, the authors describe serotype-specific expansion of intact viral particles of DENV1 and DENV2 at 28 °C (mosquitoes), 37 °C (humans) and 40 °C (fever).

  • Xin-Xiang Lim
  • , Arun Chandramohan
  •  & Ganesh S. Anand

• Article
  20 February 2015 | Open Access

  A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins

  There is no licensed vaccine or therapeutic for dengue virus (DENV) infection. Here, the authors show that a highly potent human monoclonal antibody binds to DENV particles in an unusual and very effective way by interacting with three viral envelope proteins.

  • Guntur Fibriansah
  • , Joanne L. Tan
  •  & Shee-Mei Lok

• Article | 20 May 2014

  A toggle switch controls the low pH-triggered rearrangement and maturation of the dengue virus envelope proteins

  Formation of infectious dengue virus in host cells requires a rearrangement of viral envelope proteins that is triggered by the acidic environment within secretory vesicles. Here, the authors describe the molecular mechanism underlying such rearrangement.

  • Aihua Zheng
  • , Fei Yuan
  •  & Margaret Kielian